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Xuan Zhou
Researcher at Tianjin Medical University Cancer Institute and Hospital
Publications - 80
Citations - 3791
Xuan Zhou is an academic researcher from Tianjin Medical University Cancer Institute and Hospital. The author has contributed to research in topics: Cell cycle & Cell. The author has an hindex of 30, co-authored 75 publications receiving 3183 citations. Previous affiliations of Xuan Zhou include Tianjin Medical University General Hospital & Tianjin Medical University.
Papers
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Journal ArticleDOI
Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status.
Xuan Zhou,Yu Ren,Lynette Marie Moore,Mei Mei,Yongping You,Peng Xu,Baoli Wang,Guangxiu Wang,Zhifan Jia,Peiyu Pu,Wei Zhang,Chunsheng Kang +11 more
TL;DR: Evidence is provided that miR-21 may serve as a novel therapeutic target for malignant gliomas independent of PTEN status and the GBM suppressor effect of antisense-miR- 21 is most likely independent ofPTEN regulation.
Journal ArticleDOI
The role of STAT3 in leading the crosstalk between human cancers and the immune system
TL;DR: Accumulating evidence suggests that targeting STAT3 may enhance anti-cancer immune responses and rescue the suppressed immunologic microenvironment in tumors.
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Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cadherin in oral squamous cell carcinoma
Yansheng Wu,Li Zhang,Lun Zhang,Yang Wang,Hui Li,Xiubao Ren,Feng Wei,Wenwen Yu,Ting Liu,Xudong Wang,Xuan Zhou,Jinpu Yu,Xishan Hao +12 more
TL;DR: It is shown that HotaIR expression increased in oral squamous cell carcinoma (OSCC) compared with non-tumor tissue and is associated with metastasis, the stage and histological differentiation, and overexpression of HOTAIR indicated poor overall survival (OS) and disease-free survival (DFS) in OSCC patients.
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Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner.
Kailiang Zhang,Xiaotian Sun,Xuan Zhou,Lei Han,Luyue Chen,Zhendong Shi,Anling Zhang,Minhua Ye,Qixue Wang,Chaoyong Liu,Jianwei Wei,Yu Ren,Jingxuan Yang,Jianning Zhang,Peiyu Pu,Min Li,Chunsheng Kang +16 more
TL;DR: It is found that EZH2 (predominant PRC2 complex component) inhibition blocked cell cycle progression in glioma cells, consistent with the effects elicited by HOTAIR siRNA.
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MicroRNA-21 inhibitor sensitizes human glioblastoma cells U251 (PTEN-mutant) and LN229 (PTEN-wild type) to taxol
Yu Ren,Xuan Zhou,Mei Mei,Xubo Yuan,Lei Han,Guangxiu Wang,Zhifan Jia,Peng Xu,Peiyu Pu,Chunsheng Kang +9 more
TL;DR: A combination of miR-21 inhibitor and taxol could be an effective therapeutic strategy for controlling the growth of GBM by inhibiting STAT3 expression and phosphorylation and providing an insight into the mechanism of modulating EGFR/STAT3 signaling.