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Xuejun Xie
Researcher at Fourth Military Medical University
Publications - 7
Citations - 200
Xuejun Xie is an academic researcher from Fourth Military Medical University. The author has contributed to research in topics: Clonogenic assay & Radiation therapy. The author has an hindex of 5, co-authored 7 publications receiving 190 citations. Previous affiliations of Xuejun Xie include Kyoto University.
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Journal ArticleDOI
Treatment regimen determines whether an HIF-1 inhibitor enhances or inhibits the effect of radiation therapy
Hiroshi Harada,Satoshi Itasaka,Yuxi Zhu,Lihua Zeng,Lihua Zeng,Xuejun Xie,Xuejun Xie,Akiyo Morinibu,Kazumi Shinomiya,Masahiro Hiraoka +9 more
TL;DR: The results indicate that treatment regimen determines whether an Hif-1 inhibitor enhances or inhibits the therapeutic effect of radiation, and the suppression of the postirradiation upregulation of HIF-1 activity is important for the best therapeutic benefit.
Journal ArticleDOI
Hypoxia inducible factor-1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions.
Lihua Zeng,Shinae Kizaka-Kondoh,Satoshi Itasaka,Xuejun Xie,Masahiro Inoue,Keiji Tanimoto,Keiko Shibuya,Masahiro Hiraoka +7 more
TL;DR: Data support the potential development of HIF‐1 targeted approaches in combination with PTX, where drug resistance tends to contribute to treatment failure.
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TS-1 enhances the effect of radiotherapy by suppressing radiation-induced hypoxia-inducible factor-1 activation and inducing endothelial cell apoptosis.
Lihua Zeng,Lihua Zeng,Guangfei Ou,Satoshi Itasaka,Hiroshi Harada,Xuejun Xie,Xuejun Xie,Keiko Shibuya,Shinae Kizaka-Kondoh,Akiyo Morinibu,Kazumi Shinomiya,Masahiro Hiraoka +11 more
TL;DR: Results indicate that TS‐1 enhances radiation‐induced apoptosis of endothelial cells by suppressing HIF‐1 activity, resulting in an increase in radiosensitivity of the tumor cells.
Journal ArticleDOI
Diameter of tumor blood vessels is a good parameter to estimate HIF-1-active regions in solid tumors.
Hiroshi Harada,Xuejun Xie,Xuejun Xie,Satoshi Itasaka,Lihua Zeng,Lihua Zeng,Yuxi Zhu,Akiyo Morinibu,Kazumi Shinomiya,Masahiro Hiraoka +9 more
TL;DR: A unique cancer cell line is established, which changes color HIF-1-dependently, and information about the image-guided architecture of tumor blood vessels is monitored during tumor progression to provide basic knowledge of how to estimate the spatiotemporal dynamics of HIF -1-active cells.
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P53 status plays no role in radiosensitizing effects of SN-38, a camptothecin derivative.
Xuejun Xie,Keisuke Sasai,Keiko Shibuya,Seiji Tachiiri,Keij Nihei,Takeo Ohnishi,Masahiro Hiraoka +6 more
TL;DR: The combination of irradiation and SN-38 treatment showed supraadditive effects in all four cell lines tested, and the p53 status did not play a role in the combination effect.