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Xuerong Wang
Researcher at Nanjing Medical University
Publications - 28
Citations - 1765
Xuerong Wang is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 14, co-authored 20 publications receiving 1637 citations. Previous affiliations of Xuerong Wang include Emory University.
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Journal ArticleDOI
Activation of Akt and eIF4E survival pathways by rapamycin-mediated mammalian target of rapamycin inhibition.
TL;DR: This study provides a mechanistic basis for enhancing mTOR-targeted cancer therapy by combining an mTOR inhibitor with a PI3K or Akt inhibitor and shows that rapamycin combined with LY294002 exhibited enhanced inhibitory effects on the growth and colony formation of cancer cells.
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Enhancing Mammalian Target of Rapamycin (mTOR)–Targeted Cancer Therapy by Preventing mTOR/Raptor Inhibition-Initiated, mTOR/Rictor-Independent Akt Activation
TL;DR: It is concluded that inhibition of the mTOR/raptor complex initiates Akt activation independent of m TOR/rictor, and the sustained Aktactivation during mTOR inhibition will counteract the anticancer efficacy of themTOR inhibitors.
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Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation.
Xuerong Wang,Ping Yue,Chi Bun Chan,Keqiang Ye,Takeshi Ueda,Rie Watanabe-Fukunaga,Rikiro Fukunaga,Haian Fu,Fadlo R. Khuri,Shi-Yong Sun +9 more
TL;DR: The results indicate that mTOR inhibitor-induced eIF4E phosphorylation is secondary to mTOR/raptor inhibition and independent of p70S6K, and suggest an effective therapeutic strategy for enhancing mTOR-targeted cancer therapy by cotargeting mTOR signaling and Mnk/eIF4e phosphorylated.
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Perifosine inhibits mammalian target of rapamycin signaling through facilitating degradation of major components in the mTOR axis and induces autophagy.
Lei Fu,Young-Ae Kim,Xuerong Wang,Xiaoyun Wu,Ping Yue,Sagar Lonial,Fadlo R. Khuri,Shi-Yong Sun +7 more
TL;DR: It is concluded that perifosine inhibits mTOR signaling and induces autophagy, highlighting a novel mechanism accounting for the anticancer activity of perifOSine and a potential strategy to enhance the anticancers efficacy of perIFosine by preventing autophagic.
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The alkylphospholipid perifosine induces apoptosis of human lung cancer cells requiring inhibition of Akt and activation of the extrinsic apoptotic pathway
TL;DR: It is indicated that activation of the extrinsic apoptotic pathway plays a critical role in perifosine-induced apoptosis, thus warranting future in vivo and clinical evaluation of per ifosine in combination with TRAIL in the treatment of NSCLC.