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Xuewen Kang
Researcher at Lanzhou University
Publications - 47
Citations - 434
Xuewen Kang is an academic researcher from Lanzhou University. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 20 publications receiving 80 citations.
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Journal ArticleDOI
Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function.
Guangzhi Zhang,Ya-Jun Deng,Qiqi Xie,En-Hui Ren,Zhanjun Ma,Xuegang He,Yicheng Gao,Xuewen Kang +7 more
TL;DR: The biological functions of sirtuins and the important roles of SIRT1, Sirt2, SIRT3, and SIRT6 in IDD by regulating oxidative stress, inflammatory response, and mitochondrial function are described.
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NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration.
Guangzhi Zhang,Ming-Qiang Liu,Hai-Wei Chen,Zuo-Long Wu,Yicheng Gao,Zhanjun Ma,Xuegang He,Xuewen Kang +7 more
TL;DR: In this paper, the role of the NF-κB signalling pathway in the nucleus pulposus (NP) in the process of IDD was discussed, and potential therapeutic targets that may interfere with NF-KB signalling for IDD therapy were proposed.
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Rosmarinic acid exerts a neuroprotective effect on spinal cord injury by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways.
Zhanjun Ma,Yubao Lu,Fengguang Yang,Shaoping Li,Xuegang He,Yicheng Gao,Guangzhi Zhang,En-Hui Ren,Wang Yonggang,Xuewen Kang +9 more
TL;DR: It is shown that RA improved locomotor recovery after SCI and significantly mitigated neurological deficit, increased neuronal preservation, and reduced apoptosis, which may be due to its antioxidant and anti-inflammatory properties, which are mediated by modulation of the Nrf2/HO-1 and TLR4/NF-κB pathways.
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Progress in clinical trials of cell transplantation for the treatment of spinal cord injury: how many questions remain unanswered?
TL;DR: Cell transplantation should be combined with tissue engineering scaffolds, local drug delivery systems, postoperative adjuvant therapy and physical rehabilitation training as part of a comprehensive treatment plan to provide the possibility for patients with SCI to return to normal life.
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2-arachidonyl glycerol modulates astrocytic glutamine synthetase via p38 and ERK1/2 pathways
Shenghong Wang,Hua Zhang,Bin Geng,Qiqi Xie,Wenzhou Li,Ya-Jun Deng,Weidong Shi,Yunyan Pan,Xuewen Kang,Jing Wang +9 more
TL;DR: Findings suggest that 2-AG could maintain the glutamine synthetase expression in astrocytes to a relatively stable level through modulating MAPK signaling and protect astroCytes from LPS exposure.