Journal ArticleDOI
Sirtuins and intervertebral disc degeneration: Roles in inflammation, oxidative stress, and mitochondrial function.
Guangzhi Zhang,Ya-Jun Deng,Qiqi Xie,En-Hui Ren,Zhanjun Ma,Xuegang He,Yicheng Gao,Xuewen Kang +7 more
TLDR
The biological functions of sirtuins and the important roles of SIRT1, Sirt2, SIRT3, and SIRT6 in IDD by regulating oxidative stress, inflammatory response, and mitochondrial function are described.About:
This article is published in Clinica Chimica Acta.The article was published on 2020-09-01. It has received 67 citations till now. The article focuses on the topics: Sirtuin & SIRT3.read more
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NF-κB signalling pathways in nucleus pulposus cell function and intervertebral disc degeneration.
Guangzhi Zhang,Ming-Qiang Liu,Hai-Wei Chen,Zuo-Long Wu,Yicheng Gao,Zhanjun Ma,Xuegang He,Xuewen Kang +7 more
TL;DR: In this paper, the role of the NF-κB signalling pathway in the nucleus pulposus (NP) in the process of IDD was discussed, and potential therapeutic targets that may interfere with NF-KB signalling for IDD therapy were proposed.
Journal ArticleDOI
Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo .
Saideng Lu,Yu Song,Rongjin Luo,Shuai Li,Gaocai Li,Kun Wang,Zhiwei Liao,Bingjin Wang,Wencan Ke,Qian Xiang,Chao Chen,Xinghuo Wu,Yukun Zhang,Li Ling,Cao Yang +14 more
TL;DR: In this article, the role of ferroptosis in the pathogenesis of intervertebral disc degeneration (IVDD) is investigated and the underlying regulatory mechanisms are determined.
Journal ArticleDOI
Blockchain and artificial intelligence technology in e-Health.
Priti Tagde,Sandeep Tagde,Tanima Bhattacharya,Pooja Tagde,Hitesh Chopra,Rokeya Akter,Deepak Kaushik,Md. Habibur Rahman +7 more
TL;DR: In this article, the authors focused on various aspects of blockchain and artificial intelligence and also discussed about integrating both technologies for making a significant difference in healthcare by promoting the implementation of a generalizable analytical technology that can be integrated into a more comprehensive risk management approach.
Journal ArticleDOI
Exosomes Derived from Bone Mesenchymal Stem Cells Alleviate Compression-Induced Nucleus Pulposus Cell Apoptosis by Inhibiting Oxidative Stress.
Yiqiang Hu,Ranyang Tao,Linfang Wang,Lang Chen,Ze Lin,Adriana C. Panayi,Hang Xue,Hui Li,Liming Xiong,Guohui Liu +9 more
TL;DR: In this paper, Bone mesenchymal stem cells (BMSCs-Exos) were isolated from the BMSCs and found to alleviate the inhibitory effect that compression has on proliferation and viability in NP cells, decreasing the toxic effects of compression-induced nucleus pulposus (NP) cells.
Journal ArticleDOI
Platelet-rich plasma attenuates intervertebral disc degeneration via delivering miR-141-3p-containing exosomes
TL;DR: In this article, platelet-rich plasma (PRP)-derived exosomes were isolated and purified, and both PRP-exo and ROS scavenger (NAC) reversed the detrimental effects of H2O2 treatment on the nucleus pulposus (NP) cells.
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Miller,Edward J Mills,Mojde Mirarefin,Philip B. Mitchell,Charles N Mock,Alireza Mohammadi,Shafiu Mohammed,Shafiu Mohammed,Lorenzo Monasta,Julio Cesar Montañez Hernandez,Marcella Montico,Meghan D. Mooney,Maziar Moradi-Lakeh,Maziar Moradi-Lakeh,Lidia Morawska,Ulrich O Mueller,Erin C Mullany,John Everett Mumford,M. E. Murdoch,Jean B. Nachega,Jean B. Nachega,Jean B. Nachega,Gabriele Nagel,Aliya Naheed,Luigi Naldi,Vinay Nangia,John N Newton,Marie Ng,Frida Namnyak Ngalesoni,Quyen Nguyen,Muhammad Imran Nisar,Patrick Martial Nkamedjie Pete,Joan M Nolla,Ole Frithjof Norheim,Rosana E. Norman,Bo Norrving,Bruno Pereira Nunes,Felix Akpojene Ogbo,In-Hwan Oh,Takayoshi Ohkubo,Pedro R. Olivares,Bolajoko O. Olusanya,Jacob Olusegun Olusanya,Alberto Ortiz,Majdi Osman,Erika Ota,Mahesh Pa,Eun-Kee Park,Mahboubeh Parsaeian,Valéria Maria de Azeredo Passos,Angel J Paternina Caicedo,Angel J Paternina Caicedo,Scott B. Patten,George C Patton,David M. Pereira,Rogelio Pérez-Padilla,Norberto Perico,Konrad Pesudovs,Max Petzold,Max Petzold,Michael R. Phillips,Michael R. Phillips,Frédéric B. Piel,Julian David Pillay,Farhad Pishgar,Dietrich Plass,James A Platts-Mills,Suzanne Polinder,Constance D. Pond,Svetlana Popova,Richie G Poulton,Farshad Pourmalek,Dorairaj Prabhakaran,Noela M. Prasad,Mostafa Qorbani,Rynaz H S Rabiee,Amir Radfar,Anwar Rafay,Kazem Rahimi,Vafa Rahimi-Movaghar,Mahfuzar Rahman,Mohammad Hifz Ur Rahman,Sajjad Ur Rahman,Sajjad Ur Rahman,Rajesh Kumar Rai,Sasa Rajsic,Usha Ram,Puja Rao,Amany H Refaat,Amany H Refaat,Marissa B Reitsma,Giuseppe Remuzzi,Serge Resnikoff,Alex Reynolds,Antonio Luiz Pinho Ribeiro,Maria Jesus Rios Blancas,Hirbo Shore Roba,David Rojas-Rueda,Luca Ronfani,Gholamreza Roshandel,Gholamreza Roshandel,Gregory A. Roth,Dietrich Rothenbacher,Ambuj Roy,Rajesh Sagar,Ramesh Sahathevan,Juan Sanabria,Juan Sanabria,Maria Dolores Sanchez-Niño,Itamar S. Santos,João Vasco Santos,Rodrigo Sarmiento-Suarez,Benn Sartorius,Maheswar Satpathy,Miloje Savic,Monika Sawhney,Michael Schaub,Maria Inês Schmidt,Ione Jayce Ceola Schneider,Ben Schöttker,David C. Schwebel,James Scott,Soraya Seedat,Sadaf G. Sepanlou,Edson Serván-Mori,Katya Anne Shackelford,Amira Shaheen,Masood Ali Shaikh,Rajesh Sharma,Upasana Sharma,Jiabin Shen,Jiabin Shen,Donald S. Shepard,Kevin N. Sheth,Kenji Shibuya,Min-Jeong Shin,Rahman Shiri,Ivy Shiue,Ivy Shiue,Mark G. Shrime,Inga Dora Sigfusdottir,Diego Augusto Santos Silva,Dayane Gabriele Alves Silveira,Abhishek Singh,Jasvinder A. Singh,Om Prakash Singh,Prashant Singh,Anna Sivonda,Vegard Skirbekk,Jens Christoffer Skogen,Amber Sligar,Karen Sliwa,Michael Soljak,Kjetil Søreide,Reed J D Sorensen,Joan B. Soriano,Luciano A. Sposato,Chandrashekhar T Sreeramareddy,Vasiliki Stathopoulou,Nicholas Steel,Dan J. Stein,Timothy J. Steiner,S. Steinke,Lars Jacob Stovner,Konstantinos Stroumpoulis,Bruno F. Sunguya,Patrick J Sur,Soumya Swaminathan,Bryan L. Sykes,Cassandra Szoeke,Rafael Tabarés-Seisdedos,Jukka S Takala,Nikhil Tandon,David Tanne,David Tanne,Mohammad Tavakkoli,Mohammad Tavakkoli,Bineyam Taye,Hugh R. Taylor,Braden Te Ao,Bemnet Amare Tedla,Bemnet Amare Tedla,Abdullah Sulieman Terkawi,Alan J Thomson,Andrew L. Thorne-Lyman,Andrew L. Thorne-Lyman,Amanda G. Thrift,George D Thurston,Ruoyan Tobe-Gai,Marcello Tonelli,Roman Topor-Madry,Roman Topor-Madry,Fotis Topouzis,Bach Xuan Tran,Bach Xuan Tran,Thomas Truelsen,Zacharie Tsala Dimbuene,Miltiadis K. Tsilimbaris,Abera Kenay Tura,Emin Murat Tuzcu,Stefanos Tyrovolas,Kingsley N. Ukwaja,Eduardo A. Undurraga,Chigozie Jesse Uneke,Olalekan A. Uthman,Coen H. Van Gool,Yuri Y Varakin,Tommi Vasankari,Narayanaswamy Venketasubramanian,Raj Kumar Verma,Francesco Saverio Violante,Sergey K Vladimirov,Vasiliy Victorovich Vlassov,Stein Emil Vollset,Gregory R Wagner,Gregory R Wagner,Stephen G. Waller,Linhong Wang,David A Watkins,David A Watkins,Scott Weichenthal,Elisabete Weiderpass,Robert G. Weintraub,Robert G. Weintraub,Andrea Werdecker,Ronny Westerman,Richard A. White,Hywel C Williams,Charles Shey Wiysonge,Charles Shey Wiysonge,Charles D.A. Wolfe,Charles D.A. Wolfe,Sungho Won,Rachel Woodbrook,Mamo Wubshet,Denis Xavier,Gelin Xu,Ajit Kumar Yadav,Lijing L Yan,Yuichiro Yano,Mehdi Yaseri,Mehdi Yaseri,Pengpeng Ye,Henock Yebyo,Henock Yebyo,Paul S. F. Yip,Naohiro Yonemoto,Seok Jun Yoon,Mustafa Z. Younis,Chuanhua Yu,Zoubida Zaidi,Maysaa El Sayed Zaki,Hajo Zeeb,Maigeng Zhou,Maigeng Zhou,Sanjay Zodpey,Liesl Zühlke,Christopher J L Murray +699 more
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
Journal ArticleDOI
Shared principles in NF-kappaB signaling
Matthew S. Hayden,Sankar Ghosh +1 more
TL;DR: The authors synthesize some of the basic principles that have emerged from studies of NF-kappaB, and aim to generate a more unified view of the regulation of the transcription factor.
Journal ArticleDOI
Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan
Konrad T. Howitz,Kevin J. Bitterman,Haim Y. Cohen,Dudley W. Lamming,Siva Lavu,Jason G. Wood,Robert E. Zipkin,Phuong Chung,Anne Kisielewski,Li-Li Zhang,Brandy Scherer,David A. Sinclair +11 more
TL;DR: The potent activator resveratrol, a polyphenol found in red wine, lowers the Michaelis constant of SIRT1 for both the acetylated substrate and NAD+, and increases cell survival by stimulating Sirt1-dependent deacetylation of p53.
Journal ArticleDOI
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
TL;DR: The analysis of two SIR2 mutations supports the idea that this deacetylase activity accounts for silencing, recombination suppression and extension of life span in vivo, and provides a molecular framework of NAD-dependent histone de acetylation that connects metabolism, genomic silencing and ageing in yeast and, perhaps, in higher eukaryotes.
Journal ArticleDOI
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
TL;DR: It is shown that life span regulation by the Sir proteins is independent of their role in nonhomologous end joining, and increasing the gene dosage extends the life span in wild-type cells.