X
Xun Sun
Researcher at Sichuan University
Publications - 238
Citations - 9101
Xun Sun is an academic researcher from Sichuan University. The author has contributed to research in topics: Drug delivery & Immune system. The author has an hindex of 44, co-authored 215 publications receiving 6665 citations. Previous affiliations of Xun Sun include Chinese Ministry of Education & University of Pennsylvania.
Papers
More filters
Journal ArticleDOI
Enhanced rifampicin delivery to alveolar macrophages by solid lipid nanoparticles
TL;DR: In vivo delivery efficiency and the selectivity of RFP-SLNs were further verified in Sprague–Dawley rats and demonstrated that solid lipid nanoparticles are a promising strategy for the delivery of rifampicin to alveolar macrophages selectively.
Journal ArticleDOI
Dopamine-loaded blood exosomes targeted to brain for better treatment of Parkinson's disease
Mengke Qu,Qing Lin,Luyi Huang,Yao Fu,Luyao Wang,Shanshan He,Yu Fu,Shengyong Yang,Zhirong Zhang,Ling Zhang,Xun Sun +10 more
TL;DR: It is suggested that blood exosomes can be used as a promising drug delivery platform for targeted therapy against PD and other diseases of the central nervous system.
Journal ArticleDOI
Bacteria-Driven Hypoxia Targeting for Combined Biotherapy and Photothermal Therapy
TL;DR: Both VNP and pDA potentiate the therapeutic ability of each other, resulting in a superior anticancer effect, which eliminated the tumors without relapse or metastasis with only one injection and laser irradiation.
Journal ArticleDOI
Cationic nanocarriers induce cell necrosis through impairment of Na(+)/K(+)-ATPase and cause subsequent inflammatory response.
Xiawei Wei,Bin Shao,Zhiyao He,Tinghong Ye,Min Luo,Yaxiong Sang,Xiao Liang,Wei Wang,Shun-Tao Luo,Shengyong Yang,Shuang Zhang,Changyang Gong,Maling Gou,Hongxing Deng,Yinglan Zhao,Hanshuo Yang,Senyi Deng,Chengjian Zhao,Li Yang,Zhiyong Qian,Jiong Li,Xun Sun,Jiahuai Han,Chengyu Jiang,Min Wu,Zhirong Zhang +25 more
TL;DR: The results reveal a novel mechanism whereby cationic nanocarriers induce acute cell necrosis through the interaction with Na+/K+-ATPase, with the subsequent exposure of mitochondrial damage-associated molecular patterns as a key event that mediates the inflammatory responses.
Journal ArticleDOI
Lymph node targeting strategies to improve vaccination efficacy
Hao Jiang,Qin Wang,Xun Sun +2 more
TL;DR: The critical factors that affect lymph node delivery are summarized and recently reported successful vaccine carriers are surveyed, which may be helpful for the rational design of vaccine vehicles.