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Xunda Luo
Researcher at University of Pennsylvania
Publications - 22
Citations - 827
Xunda Luo is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Retina & Retinal ganglion. The author has an hindex of 14, co-authored 22 publications receiving 713 citations. Previous affiliations of Xunda Luo include Temple University & University of Houston.
Papers
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Journal ArticleDOI
Retinal pathway origins of the pattern electroretinogram (PERG).
Xunda Luo,Laura J. Frishman +1 more
TL;DR: Transient PERG receives nearly equal amplitude contributions from ON and OFF pathways; Steady state PERG, in contrast, reflects mainly spike-related ON pathway activity.
Journal ArticleDOI
Human cone visual pigment deletions spare sufficient photoreceptors to warrant gene therapy.
Artur V. Cideciyan,Robert B. Hufnagel,Joseph Carroll,Alexander Sumaroka,Xunda Luo,Sharon B. Schwartz,Alfredo Dubra,Megan E. Land,Michel Michaelides,Jessica C. Gardner,Alison J. Hardcastle,Anthony T. Moore,Robert A. Sisk,Zubair M. Ahmed,Susanne Kohl,Bernd Wissinger,Samuel G. Jacobson +16 more
TL;DR: The evidence indicates that human cones in patients with deletions in the red/green opsin gene array can survive in reduced numbers with limited outer segment material, suggesting potential value of gene therapy for BCM.
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Adenosine, adenosine receptors and glaucoma: An updated overview
TL;DR: This article reviews recent studies on the important roles of adenosine and ARs in aqueous humor formation and outflow facility, IOP and retinal neuroprotection and suggests that the adenosines system is one of the potential target systems for therapeutic approaches in glaucoma.
Journal ArticleDOI
Reproducibility of measuring lamina cribrosa pore geometry in human and nonhuman primates with in vivo adaptive optics imaging.
Kevin M. Ivers,Chaohong Li,Nimesh B. Patel,Nripun Sredar,Xunda Luo,Hope M Queener,Ronald S. Harwerth,Jason Porter +7 more
TL;DR: The small intersession variability in normal pore geometry suggests that AOSLO imaging could be used to measure and track changes in laminar pores in vivo during glaucomatous progression.
Journal ArticleDOI
Abnormal thickening as well as thinning of the photoreceptor layer in intermediate age-related macular degeneration.
Sam Sadigh,Artur V. Cideciyan,Alexander Sumaroka,Wei Chieh Huang,Xunda Luo,Malgorzata Swider,Janet D. Steinberg,Dwight Stambolian,Samuel G. Jacobson +8 more
TL;DR: Reductions in the photoreceptor laminae overlying drusen were detectable and this is consistent with histological studies revealing neuronal degeneration in AMD, and ONL thickening in some macular areas of AMD eyes has not been previously reported and may be an early phenotypic marker for Photoreceptor stress.