D
Dwight Stambolian
Researcher at University of Pennsylvania
Publications - 149
Citations - 17298
Dwight Stambolian is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Macular degeneration & Population. The author has an hindex of 45, co-authored 136 publications receiving 13482 citations. Previous affiliations of Dwight Stambolian include Children's Hospital of Philadelphia & Scheie Eye Institute.
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Journal ArticleDOI
Next-generation genotype imputation service and methods.
Sayantan Das,Lukas Forer,Sebastian Schönherr,Carlo Sidore,Carlo Sidore,Adam E. Locke,Alan Kwong,Scott I. Vrieze,Emily Y. Chew,Shawn Levy,Matt McGue,David Schlessinger,Dwight Stambolian,Po-Ru Loh,William G. Iacono,Anand Swaroop,Laura J. Scott,Francesco Cucca,Florian Kronenberg,Michael Boehnke,Gonçalo R. Abecasis,Christian Fuchsberger,Christian Fuchsberger,Christian Fuchsberger +23 more
TL;DR: Improvements to imputation machinery are described that reduce computational requirements by more than an order of magnitude with no loss of accuracy in comparison to standard imputation tools.
Journal ArticleDOI
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,C Sidore,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Chen,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +117 more
TL;DR: A reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry leads to accurate genotype imputation at minor allele frequencies as low as 0.1% and a large increase in the number of SNPs tested in association studies.
Journal ArticleDOI
Global Causes of Blindness and Distance Vision Impairment 1990-2020: A Systematic Review and Meta-Analysis
Seth Flaxman,Rupert R A Bourne,Serge Resnikoff,Serge Resnikoff,Peter Ackland,Tasanee Braithwaite,Maria V Cicinelli,Aditi Das,Jost B. Jonas,Jill E Keeffe,John H. Kempen,Janet L Leasher,Hans Limburg,Kovin Naidoo,Kovin Naidoo,Konrad Pesudovs,Alexander J Silvester,Gretchen A Stevens,Nina Tahhan,Nina Tahhan,Tien Yin Wong,Hugh R. Taylor,Rupert R A Bourne,Aries Arditi,Yaniv Barkana,Banu Bozkurt,Alain M. Bron,Donald L. Budenz,Feng Cai,Robert J Casson,Usha Chakravarthy,Jaewan Choi,Maria Vittoria Cicinelli,Nathan Congdon,Reza Dana,Rakhi Dandona,Lalit Dandona,Iva Dekaris,Monte A. Del Monte,Jenny deva,Laura E. Dreer,Leon B. Ellwein,Marcela Frazier,Kevin D. Frick,David S. Friedman,João M. Furtado,H. Gao,Gus Gazzard,Ronnie George,Stephen Gichuhi,Victor H. Gonzalez,Billy R. Hammond,Mary Elizabeth Hartnett,Minguang He,James F. Hejtmancik,Flavio E. Hirai,John J Huang,April D. Ingram,Jonathan C. Javitt,Jost B. Jonas,Charlotte E. Joslin,John H Kempen,Moncef Khairallah,Rohit C Khanna,Judy E. Kim,George N. Lambrou,Van C. Lansingh,Paolo Lanzetta,Jennifer I. Lim,Kaweh Mansouri,Anu A. Mathew,Alan R. Morse,Beatriz Munoz,David C. Musch,Vinay Nangia,Maria Palaiou,Maurizio Battaglia Parodi,Fernando Yaacov Pena,Tunde Peto,Harry A. Quigley,Murugesan Raju,Pradeep Y. Ramulu,Zane Rankin,Dana Reza,Alan L. Robin,Luca Rossetti,Jinan B. Saaddine,Mya Sandar,Janet B. Serle,Tueng T. Shen,Rajesh K. Shetty,Pamela C. Sieving,Juan Carlos Silva,Rita S. Sitorus,Dwight Stambolian,Gretchen Stevens,Hugh Taylor,Jaime Tejedor,James M. Tielsch,Miltiadis K. Tsilimbaris,Jan C. van Meurs,Rohit Varma,Gianni Virgili,Ya Xing Wang,Ningli Wang,Sheila K. West,Peter Wiedemann,Tien Wong,Richard Wormald,Yingfeng Zheng +109 more
TL;DR: A series of regression models were fitted to estimate the proportion of moderate or severe vision impairment and blindness by cause, age, region, and year, and found that world regions varied markedly in the causes of blindness and vision impairment in this age group.
Journal ArticleDOI
Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis
Rupert R A Bourne,Seth Flaxman,Tasanee Braithwaite,Maria V Cicinelli,Aditi Das,Jost B. Jonas,Jill E Keeffe,John H Kempen,Janet L Leasher,Hans Limburg,Kovin Naidoo,Kovin Naidoo,Konrad Pesudovs,Serge Resnikoff,Serge Resnikoff,Alexander J Silvester,Gretchen A Stevens,Nina Tahhan,Nina Tahhan,Tien Yin Wong,Hugh R. Taylor,Rupert R A Bourne,Peter Ackland,Aries Arditi,Yaniv Barkana,Banu Bozkurt,Alain M. Bron,Donald L. Budenz,Feng Cai,Robert J Casson,Usha Chakravarthy,Jaewan Choi,Maria Vittoria Cicinelli,Nathan Congdon,Reza Dana,Rakhi Dandona,Lalit Dandona,Iva Dekaris,Monte A. Del Monte,Jenny deva,Laura Dreer,Leon B. Ellwein,Marcela Frazier,Kevin D. Frick,David S. Friedman,João M. Furtado,H. Gao,Gus Gazzard,Ronnie George,Stephen Gichuhi,Victor H. Gonzalez,Billy R. Hammond,Mary Elizabeth Hartnett,Minguang He,James F. Hejtmancik,Flavio E. Hirai,John J Huang,April D. Ingram,Jonathan C. Javitt,Jost B. Jonas,Charlotte E. Joslin,John H. Kempen,John H. Kempen,Moncef Khairallah,Rohit C Khanna,Judy E. Kim,George N. Lambrou,Van C. Lansingh,Paolo Lanzetta,Jennifer I. Lim,Kaweh Mansouri,Anu A. Mathew,Alan R. Morse,Beatriz Munoz,David C. Musch,Vinay Nangia,Maria Palaiou,Maurizio Battaglia Parodi,Fernando Yaacov Pena,Tunde Peto,Harry A. Quigley,Murugesan Raju,Pradeep Y. Ramulu,Alan L. Robin,Luca Rossetti,Jinan B. Saaddine,Mya Sandar,Janet B. Serle,Tueng T. Shen,Rajesh K. Shetty,Pamela C. Sieving,Juan Carlos Silva,Rita S. Sitorus,Dwight Stambolian,Gretchen Stevens,Hugh Taylor,Jaime Tejedor,James M. Tielsch,Miltiadis K. Tsilimbaris,Jan C. van Meurs,Rohit Varma,Gianni Virgili,Jimmy Volmink,Ya Xing Wang,Ningli Wang,Sheila K. West,Peter Wiedemann,Tien Wong,Richard Wormald,Yingfeng Zheng +109 more
TL;DR: There is an ongoing reduction in the age-standardised prevalence of blindness and visual impairment, yet the growth and ageing of the world's population is causing a substantial increase in number of people affected, highlighting the need to scale up vision impairment alleviation efforts at all levels.
A reference panel of 64,976 haplotypes for genotype imputation
Shane A. McCarthy,Sayantan Das,Warren W. Kretzschmar,Olivier Delaneau,Andrew R. Wood,Alexander Teumer,Hyun Min Kang,Christian Fuchsberger,Petr Danecek,Kevin Sharp,Yang Luo,Carlo Sidorel,Alan Kwong,Nicholas J. Timpson,Seppo Koskinen,Scott I. Vrieze,Laura J. Scott,He Zhang,Anubha Mahajan,Jan H. Veldink,Ulrike Peters,Carlos N. Pato,Cornelia M. van Duijn,Christopher E. Gillies,Ilaria Gandin,Massimo Mezzavilla,Arthur Gilly,Massimiliano Cocca,Michela Traglia,Andrea Angius,Jeffrey C. Barrett,D.I. Boomsma,Kari Branham,Gerome Breen,Chad M. Brummett,Fabio Busonero,Harry Campbell,Andrew T. Chan,Sai Che,Emily Y. Chew,Francis S. Collins,Laura J Corbin,George Davey Smith,George Dedoussis,Marcus Dörr,Aliki-Eleni Farmaki,Luigi Ferrucci,Lukas Forer,Ross M. Fraser,Stacey Gabriel,Shawn Levy,Leif Groop,Tabitha A. Harrison,Andrew T. Hattersley,Oddgeir L. Holmen,Kristian Hveem,Matthias Kretzler,James Lee,Matt McGue,Thomas Meitinger,David Melzer,Josine L. Min,Karen L. Mohlke,John B. Vincent,Matthias Nauck,Deborah A. Nickerson,Aarno Palotie,Michele T. Pato,Nicola Pirastu,Melvin G. McInnis,J. Brent Richards,Cinzia Sala,Veikko Salomaa,David Schlessinger,Sebastian Schoenherr,P. Eline Slagboom,Kerrin S. Small,Tim D. Spector,Dwight Stambolian,Marcus A. Tuke,Jaakko Tuomilehto,Leonard H. van den Berg,Wouter van Rheenen,Uwe Völker,Cisca Wijmenga,Daniela Toniolo,Eleftheria Zeggini,Paolo Gasparini,Matthew G. Sampson,James F. Wilson,Timothy M. Frayling,Paul I.W. de Bakker,Morris A. Swertz,Steven A. McCarroll,Charles Kooperberg,Annelot M. Dekker,David Altshuler,Cristen J. Willer,William G. Iacono,Samuli Ripatti,Nicole Soranzo,Klaudia Walter,Anand Swaroop,Francesco Cucca,Carl A. Anderson,Richard M. Myers,Michael Boehnke,Mark I. McCarthy,Richard Durbin,Gonçalo R. Abecasis,Jonathan Marchini +110 more
TL;DR: In this article, a reference panel of 64,976 human haplotypes at 39,235,157 SNPs constructed using whole-genome sequence data from 20 studies of predominantly European ancestry is presented.