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Y. Bill Kim
Researcher at Howard Hughes Medical Institute
Publications - 3
Citations - 1180
Y. Bill Kim is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Genome editing & Cas9. The author has an hindex of 3, co-authored 3 publications receiving 840 citations. Previous affiliations of Y. Bill Kim include Broad Institute & Harvard University.
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Journal ArticleDOI
Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions
Y. Bill Kim,Y. Bill Kim,Alexis C. Komor,Alexis C. Komor,Jonathan M. Levy,Jonathan M. Levy,Michael S. Packer,Michael S. Packer,Kevin T. Zhao,Kevin T. Zhao,David R. Liu,David R. Liu,David R. Liu +12 more
TL;DR: Five C to T (or G to A) base editors that use natural and engineered Cas9 variants with different protospacer-adjacent motif (PAM) specificities to expand the number of sites that can be targeted by base editing 2.5-fold are reported.
Journal ArticleDOI
Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity.
Alexis C. Komor,Alexis C. Komor,Alexis C. Komor,Kevin T. Zhao,Kevin T. Zhao,Kevin T. Zhao,Michael S. Packer,Michael S. Packer,Michael S. Packer,Nicole M. Gaudelli,Nicole M. Gaudelli,Nicole M. Gaudelli,Amanda L. Waterbury,Luke W. Koblan,Luke W. Koblan,Luke W. Koblan,Y. Bill Kim,Y. Bill Kim,Y. Bill Kim,Ahmed H. Badran,Ahmed H. Badran,Ahmed H. Badran,David R. Liu,David R. Liu,David R. Liu +24 more
TL;DR: Fourth-generation base editors (BE4 and SaBE4) are engineered that increase the efficiency of C:G to T:A base editing by approximately 50%, while halving the frequency of undesired by-products compared to BE3, and recommend their use in future efforts.
Journal ArticleDOI
An anionic human protein mediates cationic liposome delivery of genome editing proteins into mammalian cells.
Y. Bill Kim,Y. Bill Kim,Y. Bill Kim,Kevin T. Zhao,Kevin T. Zhao,Kevin T. Zhao,David B. Thompson,David B. Thompson,David R. Liu,David R. Liu,David R. Liu +10 more
TL;DR: The authors discover that ProTα, a small, intrinsically disordered human protein can facilitate efficient cationic lipid-mediated protein delivery of genome editing proteins into mammalian cells.