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Ya-Chu Chang
Researcher at National Tsing Hua University
Publications - 17
Citations - 378
Ya-Chu Chang is an academic researcher from National Tsing Hua University. The author has contributed to research in topics: AAA proteins & Cas9. The author has an hindex of 8, co-authored 15 publications receiving 280 citations. Previous affiliations of Ya-Chu Chang include National Taiwan University & University of Minnesota.
Papers
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Journal ArticleDOI
Deregulated microRNAs in triple-negative breast cancer revealed by deep sequencing
Yao-Yin Chang,Wen-Hung Kuo,Jui-Hui Hung,Jui-Hui Hung,Chien-Yueh Lee,Chien-Yueh Lee,Yung-Hua Lee,Ya-Chu Chang,Wen-Chun Lin,Cheng-Ying Shen,Chiun-Sheng Huang,Fon-Jou Hsieh,Liang-Chuan Lai,Mong-Hsun Tsai,King-Jen Chang,Eric Y. Chuang,Eric Y. Chuang +16 more
TL;DR: A novel 25-miRNA expression signature was found to effectively distinguish triple-negative breast cancers from surrounding normal tissues in a hierarchical clustering analysis, and implicate a miR-130b-5p-CCNG2 axis that may be involved in the malignant progression of triple- negative breast cancer.
Journal ArticleDOI
Pathogenic VCP/TER94 Alleles Are Dominant Actives and Contribute to Neurodegeneration by Altering Cellular ATP Level in a Drosophila IBMPFD Model
Ya-Chu Chang,Wan-Tzu Hung,Yun-Chin Chang,Henry C. Chang,Chia-Lin Wu,Ann-Shyn Chiang,George R. Jackson,Tzu-Kang Sang +7 more
TL;DR: It is shown that increasing cellular ATP by independent mechanisms could suppress the phenotypes of TER94 mutants and decreasing cellular ATP would enhance the TER94 mutant phenotypes, making an unexpected link between cellular ATP level and IBMPFD pathogenesis.
Journal ArticleDOI
Spatiotemporal manipulation of ciliary glutamylation reveals its roles in intraciliary trafficking and Hedgehog signaling.
Shi Rong Hong,Cuei Ling Wang,Yao Shen Huang,Yu Chen Chang,Ya-Chu Chang,Ganesh V. Pusapati,Chun Yu Lin,Ning Hsu,Hsiao Chi Cheng,Yueh Chen Chiang,Wei En Huang,Nathan C. Shaner,Rajat Rohatgi,Takanari Inoue,Yu-Chun Lin +14 more
TL;DR: A method to rapidly deplete tubulin glutamylation inside the primary cilia, a microtubule-based sensory organelle protruding on the cell surface, by targeting an engineered deglutamylase to the cilia in minutes is developed.
Journal ArticleDOI
Sonogenetic Modulation of Cellular Activities Using an Engineered Auditory-Sensing Protein
Yao Shen Huang,Ching Hsiang Fan,Ning Hsu,Nai Hua Chiu,Chun Yao Wu,Chu Yuan Chang,Bing Huan Wu,Shi Rong Hong,Ya-Chu Chang,Anthony Yan-Tang Wu,Anthony Yan-Tang Wu,Vanessa Guo,Yueh Chen Chiang,Wei Chia Hsu,Linyi Chen,Charles P. Lai,Charles P. Lai,Chih-Kuang Yeh,Yu-Chun Lin +18 more
TL;DR: A sonogenetic approach that can manipulate target cell activities by focused ultrasound stimulation derived from an engineered auditory-sensing protein prestin is reported, which will serve as new strategies for non-invasive therapy in deep tissues.
Journal ArticleDOI
MicroRNA-769-3p Down-regulates NDRG1 and Enhances Apoptosis in MCF-7 Cells During Reoxygenation
En-Ching Luo,Ya-Chu Chang,Yuh Pyng Sher,Wei Yung Huang,Li-ling Chuang,Yu-Chiao Chiu,Mong-Hsun Tsai,Eric Y. Chuang,Liang-Chuan Lai +8 more
TL;DR: It is revealed that miR-769-3p can functionally regulate NDRG1 during changes in oxygen concentration, which caused a significant reduction of N DRG1 protein upon reoxygenation.