https://serval.unil.ch/resource/serval:BIB_89872BC6E950.P001/REF

BAFF, APRIL and their receptors: structure, function and signaling.

Purpose: Recent studies suggest that donor B cells as well as T cells contribute to immune pathology in patients with chronic graft-versus-host disease (GVHD). B-cell activating factor (BAFF) promotes survival and differentiation of activated B cells. Thus, we tested whether BAFF correlated with chronic GVHD disease activity and time of onset after allogeneic hematopoietic stem cell transplantation (HSCT). Experimental Design: Patients who had undergone allogeneic HSCT between 1994 and 2005 for hematologic malignancies were studied. ELISA was used to measure plasma BAFF levels and flow cytometry was used to assess BAFF receptor expression on B cells in patients with or without chronic GVHD. Results: In 104 patients, BAFF levels were significantly higher in patients with active chronic GVHD compared with those without disease ( P = 0.02 and 0.0004, respectively). Treatment with high-dose prednisone (≥30 mg/d) was associated with reduced BAFF levels in patients with active chronic GVHD ( P = 0.0005). Serial studies in 24 patients showed that BAFF levels were high in the first 3 months after HSCT but subsequently decreased in 13 patients who never developed chronic GVHD. In contrast, BAFF levels remained elevated in 11 patients who developed chronic GVHD. Six-month BAFF levels ≥10 ng/mL were strongly associated with subsequent development of chronic GVHD ( P P = 0.01), suggesting that soluble BAFF affected B cells through this receptor. Conclusion: These results suggest that elevated BAFF levels contribute to B-cell activation in patients with active chronic GVHD.

https://clincancerres.aacrjournals.org/content/clincanres/13/20/6107.full.pdf

High levels of B-cell activating factor in patients with active chronic graft-versus-host disease.

The role of the BAFF/APRIL system on T cell function.

TACI, an enigmatic BAFF/APRIL receptor, with new unappreciated biochemical and biological properties

BAFF and selection of autoreactive B cells

https://escholarship.org/content/qt7501p47p/qt7501p47p.pdf?t=lnpz6b

TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.

Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes.

Yaiza Diaz-de-Durana

Papers

TACI-BLyS signaling via B-cell-dendritic cell cooperation is required for naive CD8+ T-cell priming in vivo.

Life-long systemic protection in mice vaccinated with L. major and adenovirus IL-12 vector requires active infection, macrophages and intact lymph nodes.