Yalai Bai

TL;DR: T tumor phylogenetics is performed using molecular evolutionary models, reconstructed ancestral states of somatic mutations, and inferred cancer chronograms to yield three conclusions, one of which is that in contrast to a linear model of cancer progression, metastases can originate from divergent lineages within primary tumors.

TL;DR: This work establishes an immunologic stimulus for mTORC1 signaling in vascular smooth muscle cells, emphasizes that m TORC1 activation is critical in immune-mediated vascular remodeling, and provides further mechanistic insight into the successful clinical application of rapamycin therapy for atherosclerosis and graft arteriosclerosis.

TL;DR: The reproducibility of Ki67 measurement between three image analysis platforms with supervised classifiers performed by the same operator, by multiple operators, and finally in prognostic potential is investigated to justify multi-institutional DIA studies to assess clinical utility.

TL;DR: Recruitment of allogeneic T cells to different vascular compartments correlated with the expression of chemokines and their receptors are investigated, and the suggestion that the arterial media may be a site of immunological privilege is reinforced.

TL;DR: Automated machine assessment of average Ki67 has the potential to achieve between-laboratory reproducibility similar to that for a rigorously standardized pathologist-based visual assessment of Ki67, but requires further standardization and subsequent clinical validation.