Zi-Ming Zhao

TL;DR: It is concluded that ancient Trxs use chemical mechanisms of reduction similar to those of modern enzymes, which have adapted over 4 Gyr to the changes in temperature and ocean acidity that characterize the evolution of the global environment from ancient to modern Earth.

TL;DR: This study performs whole-exome sequencing and immune profiling analyses of a unique set of clinically annotated early-stage LUADs to better understand the pathogenesis of this disease and identify clinically relevant molecular markers.

TL;DR: T tumor phylogenetics is performed using molecular evolutionary models, reconstructed ancestral states of somatic mutations, and inferred cancer chronograms to yield three conclusions, one of which is that in contrast to a linear model of cancer progression, metastases can originate from divergent lineages within primary tumors.

TL;DR: In this paper, the authors exhaustively analyzed copy number alterations in 1,451 PDX and matched patient tumor (PT) samples from 509 PDX models, and they showed strong CNA conservation from PTs through late-passage PDXs.

TL;DR: Analysis of mutations with immune markers revealed that ADCY8 and PIK3CA mutations were associated with markedly decreased tumoral PD-L1 expression, LUSCs with PIK 3CA mutations exhibited elevated CD45ro levels and CDKN2A-mutant tumors displayed an up-regulated immune response.