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Yan-Ai Mei
Researcher at Fudan University
Publications - 66
Citations - 1390
Yan-Ai Mei is an academic researcher from Fudan University. The author has contributed to research in topics: Receptor & Protein kinase C. The author has an hindex of 20, co-authored 66 publications receiving 1128 citations.
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Journal ArticleDOI
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
Zhaoyang Li,Cen Wang,Ziying Wang,Chenggang Zhu,Jie Li,Tian Sha,Lixiang Ma,Chao Gao,Yi Yang,Yimin Sun,Jian Wang,Xiaoli Sun,Chenqi Lu,Marian DiFiglia,Yan-Ai Mei,Chen Ding,Shouqing Luo,Yongjun Dang,Yu Ding,Yiyan Fei,Boxun Lu +20 more
TL;DR: Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant Huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.
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Extremely Low Frequency Electromagnetic Fields Facilitate Vesicle Endocytosis by Increasing Presynaptic Calcium Channel Expression at a Central Synapse.
Zhi-cheng Sun,Jian-long Ge,Bin Guo,Jun Guo,Mei Hao,Yichen Wu,Yi-an Lin,Ting La,Pan-tong Yao,Yan-Ai Mei,Yi Feng,Lei Xue +11 more
TL;DR: Exposure to ELF-EMF facilitates vesicle endocytosis and synaptic plasticity in a calcium-dependent manner by increasing calcium channel expression at the nerve terminal by directly measuring calcium currents and membrane capacitance at a large mammalian central nervous synapse.
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4-aminopyridine, a Kv channel antagonist, prevents apoptosis of rat cerebellar granule neurons.
TL;DR: The results suggest that 4-AP has robust neuroprotective effects on apoptotic granule cells, and may modulate the gating properties of IA channels in an anti-apoptotic manner.
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Exposure to extremely low-frequency electromagnetic fields modulates Na+ currents in rat cerebellar granule cells through increase of AA/PGE2 and EP receptor-mediated cAMP/PKA pathway.
TL;DR: Together, these data demonstrate for the first time that neuronal I Na is significantly increased by ELF-EMF exposure via a cPLA2 AA PGE2 EP receptors PKA signaling pathway.
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cAMP/protein kinase A signalling pathway protects against neuronal apoptosis and is associated with modulation of Kv2.1 in cerebellar granule cells.
TL;DR: The protection against apoptosis via the protein kinase A pathway is associated with a double modulation on IK channel properties and its expression of α‐subunit that is mainly encoded by the Kv2.1 gene.