L
Lixiang Ma
Researcher at Fudan University
Publications - 22
Citations - 648
Lixiang Ma is an academic researcher from Fudan University. The author has contributed to research in topics: Huntingtin Protein & Induced pluripotent stem cell. The author has an hindex of 11, co-authored 22 publications receiving 372 citations. Previous affiliations of Lixiang Ma include Fudan University Shanghai Medical College.
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Journal ArticleDOI
Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds
Zhaoyang Li,Cen Wang,Ziying Wang,Chenggang Zhu,Jie Li,Tian Sha,Lixiang Ma,Chao Gao,Yi Yang,Yimin Sun,Jian Wang,Xiaoli Sun,Chenqi Lu,Marian DiFiglia,Yan-Ai Mei,Chen Ding,Shouqing Luo,Yongjun Dang,Yu Ding,Yiyan Fei,Boxun Lu +20 more
TL;DR: Compounds that interact with mutant huntingtin and an autophagosomal protein are able to reduce cellular levels of mutant Huntingtin by targeting it for autophagic degradation, demonstrating an approach that may have potential for treating proteopathies.
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A striatal-enriched intronic GPCR modulates huntingtin levels and toxicity
Yuwei Yao,Xiaotian Cui,Ismael Al-Ramahi,Xiaoli Sun,Bo Li,Jiapeng Hou,Marian DiFiglia,James Palacino,Zhi-Ying Wu,Lixiang Ma,Juan Botas,Boxun Lu +11 more
TL;DR: A striatal-enriched orphan G protein-coupled receptor(GPCR) Gpr52 is reported as a stabilizer of Htt in vitro and in vivo, providing insights into the selective neurodegeneration and potential treatment strategies.
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Clinical spectrum and genetic landscape for hereditary spastic paraplegias in China.
En-Lin Dong,Chong Wang,Shuang Wu,Ying-Qian Lu,Xiao-Hong Lin,Hui-Zhen Su,Miao Zhao,Jin He,Lixiang Ma,Ning Wang,Wan-Jin Chen,Xiang Lin +11 more
TL;DR: This study presents a comprehensive clinical spectrum and genetic landscape for HSP in China, and observed significantly different patterns of mitochondrial dynamics and network, decreased mitochondrial membrane potential, increased reactive oxygen species and reduced ATP content in SPG4 fibroblasts.
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Suppression of MAPK11 or HIPK3 reduces mutant Huntingtin levels in Huntington's disease models.
Meng Yu,Yuhua Fu,Yijiang Liang,Haikun Song,Yao Yao,Peng Wu,Yuwei Yao,Yuyin Pan,Xue Wen,Lixiang Ma,Saiyin Hexige,Yu Ding,Shouqing Luo,Boxun Lu +13 more
TL;DR: Two kinases HIPK3 and MAPK11 are reported as positive modulators of mHTT levels both in cells and in vivo, revealing new therapeutic entry points for HD and target-discovery approaches for similar diseases.
Journal ArticleDOI
Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine.
Wenqing Gong,Shanshan Zhang,Ying Zong,Michael Halim,Zhonggan Ren,Ya-Lin Wang,Yuanyuan Ma,Bing Li,Lixiang Ma,Guomin Zhou,Jin Yu,Junhai Zhang,Qiong Liu +12 more
TL;DR: Results imply that clomipramine could attenuate depressive behaviors and neuroinflammation induced by LPS via partial regulation of NLRP3.