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Yan-jun Gan
Researcher at St. Jude Children's Research Hospital
Publications - 7
Citations - 1320
Yan-jun Gan is an academic researcher from St. Jude Children's Research Hospital. The author has contributed to research in topics: Epstein–Barr virus & Virus. The author has an hindex of 6, co-authored 7 publications receiving 1301 citations. Previous affiliations of Yan-jun Gan include University of Tennessee Health Science Center & Louisiana State University.
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Journal ArticleDOI
Infusion of Cytotoxic T Cells for the Prevention and Treatment of Epstein-Barr Virus–Induced Lymphoma in Allogeneic Transplant Recipients
Cliona M. Rooney,Colton Smith,Colton Smith,Catherine Y.C. Ng,Catherine Y.C. Ng,Susan K. Loftin,Susan K. Loftin,John W. Sixbey,John W. Sixbey,Yan-jun Gan,Yan-jun Gan,Deo Kumar Srivastava,Deo Kumar Srivastava,Laura C. Bowman,Laura C. Bowman,Robert A. Krance,Robert A. Krance,Malcolm K. Brenner,Helen E. Heslop,Helen E. Heslop +19 more
TL;DR: Polyclonal donor-derived T-cell lines specific for EBV proteins can be used safely to prevent EBV-related immunoblastic lymphoma after allogeneic marrow transplantation and may also be effective in the treatment of established disease.
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Detection of Cell-Free Epstein-Barr Virus DNA in Serum during Acute Infectious Mononucleosis
TL;DR: Sera from 125 persons with heterophil-positive acute infectious mononucleosis or EBV-associated nasopharyngeal carcinoma or who were healthy virus carriers were examined for evidence of cell-free viral DNA, and viral DNA was found in concert with one serologic marker of acute infection,EBV-specific polymeric IgA.
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Epithelial cell polarization is a determinant in the infectious outcome of immunoglobulin A-mediated entry by Epstein-Barr virus.
TL;DR: PIgR-mediated transcytosis of pIgA-EBV through epithelium facilitates endogenous spread of EBV in long-term virus carriers, with infection being confined to cells with altered polarity from prior cytopathology.
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Detection of Epstein—Barn Virus Genome in Ocular Tissues
TL;DR: The frequency with which EBV was found at apparently normal ocular sites raises the possibility for viral involvement in disease states, but emphasizes the need for specific criteria to implicate EBV in ocular pathology.
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Patterned entry and egress by Epstein-Barr virus in polarized CR2-positive epithelial cells.
TL;DR: Under conditions of long-term culture, latent EBV was not stably maintained in these cells, suggesting that the epithelial phase of acute EBV infection may be transient.