Yan-Qing Liu

TL;DR: A comprehensive overview of the applications of asymmetric organocatalysis in medicinal chemistry can be found in this article, with a focus on the preparation of antiviral, anticancer, neuroprotective, cardiovascular, antibacterial, and antiparasitic agents, as well as several miscellaneous bioactive agents.

TL;DR: With this protocol, over 120 examples of functionalized ketones with diverse fluorine substituents have been facilely synthesized in up to 99% yield with complete regioselectivity with preliminary results on the catalytic asymmetric variant of the olefin difunctionalization process.

TL;DR: P palladium-catalyzed, regiodivergent[5 + 4] and [5 + 2] annulations of vinylethylene carbonates and allylidenemalononitriles are reported, describing the production of over 50 examples of nine- and seven-membered heterocycles in high isolated yields and excellent regioselectivities.

TL;DR: The 6,8-dioxabicyclo[3.2.1] octane (6,8 -DOBCO) architecture widely exists in a broad spectrum of bioactive natural products, and the development of efficient and convenient protocols to construct th...

TL;DR: A highly chemo- and diastereoselective cyclization of vinylethylene carbonates and 5-alkenyl thiazolones through palladium catalysis and a variety of amide monothioacetals (AMTA) with two quaternary stereocenters are facilely synthesized.