Y
Yang Li
Researcher at Huazhong University of Science and Technology
Publications - 12
Citations - 282
Yang Li is an academic researcher from Huazhong University of Science and Technology. The author has contributed to research in topics: Insulin & Amyloid. The author has an hindex of 9, co-authored 11 publications receiving 185 citations.
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Journal ArticleDOI
Disulfide bonds in amyloidogenesis diseases related proteins.
TL;DR: The role of disulfide on the stability, structure, oligomerization, and amyloidogenecity of native folded or unfolded amyloidsogenic proteins is focused on.
Journal ArticleDOI
Dissecting the role of disulfide bonds on the amyloid formation of insulin.
Yang Li,Hao Gong,Yue Sun,Juan Yan,Biao Cheng,Xin Zhang,Jing Huang,Mengying Yu,Yu Guo,Ling Zheng,Kun Huang +10 more
TL;DR: The results indicated that breakage of A7-B7 induced more unfolding of the insulin structure and a higher amyloidogenicity than breakages of A6-A11, but breakages caused a significant cytotoxicity increase and aHigher potency to form high order toxic oligomers.
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C-terminal truncation exacerbates the aggregation and cytotoxicity of α-Synuclein: A vicious cycle in Parkinson's disease.
TL;DR: A hidden vicious cycle in PD is suggested that α-Syn121 rapidly forms amorphous aggregates, which activate caspase-1 to cleave α- Syn FL and generate more α-syn121, and this cycle may contribute to the onset and/or pathogenesis of PD.
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Copper and iron ions accelerate the prion-like propagation of α-synuclein: A vicious cycle in Parkinson's disease
Yang Li,Chen Yang,Shilin Wang,Dong Yang,Yu Zhang,Li Xu,Liang Ma,Jiaojiao Zheng,Robert B. Petersen,Ling Zheng,Hong Chen,Kun Huang +11 more
TL;DR: It is reported that copper/iron ions accelerate prion-like propagation of α-synuclein fibrils by promoting cellular internalization of α -synucle in fibril, intracellular α- synuclein aggregation and the subsequent release of mature fibrs to the extracellular space to induce further propagation.
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Interaction between amyloidogenic proteins and biomembranes in protein misfolding diseases: Mechanisms, contributors, and therapy.
TL;DR: A comprehensive review of the mechanisms and contributing factors of the interaction between biomembranes and amyloidogenic proteins, and a summary of the therapeutic approaches to PMDs that target this interaction are provided.