Showing papers in "Biochemical and Biophysical Research Communications in 2012"

TL;DR: Lipasin is a novel nutritionally-regulated liver-enriched factor that plays a role in lipid metabolism, and a potential mechanism for Lipasin-mediated triglyceride elevation is through reduced triglyceride clearance by LPL inhibition.

TL;DR: In this article, the authors have discussed a number of diabetes-induced metabolites such as glucose, advanced glycation end products, protein kinase C and oxidative stress and other related factors that are implicated in the pathophysiology of diabetic retinopathy.

TL;DR: A parallel tool - ParaAT that is capable of parallelly constructing multiple protein-coding DNA alignments for a large number of homologs and providing good scalability and exhibiting high parallel efficiency for computationally demanding tasks is presented.

TL;DR: MEK1 and MEK2 are related protein kinases that participate in the RAS-RAF-MEK-ERK signal transduction cascade that participates in the regulation of a large variety of processes including apoptosis, cell cycle progression, cell migration, differentiation, metabolism, and proliferation.

TL;DR: In the present review some of the known features of ACLY such as tissue distribution, subcellular localization, enzymatic properties, gene regulation and associated physiological conditions are highlighted.

TL;DR: It is found that miR-199a-5p levels were significantly reduced in HCC patients treated with cisplatin-based chemotherapy, thus offering a new target for chemotherapy of HCC.

TL;DR: In vivo detection of GSH non-invasively from various brain regions in bilateral hemispheres of healthy male and female subjects and from bi-lateral frontal cortices in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD) is reported.

TL;DR: This study demonstrates that the T GR5 expressed in the pancreatic β cells regulates insulin secretion and highlights the importance of ongoing therapeutic strategies targeting TGR5 in the control of glucose homeostasis.

TL;DR: The findings suggest that caspase-1 plays a critical role in vascular inflammation and atherosclerosis, and that modulation of caspASE-1 could be a potential target for prevention and treatment of Atherosclerosis.

TL;DR: It is suggested that cardiac cell sheets formed by hiPSC-derived cardiomyocytes might have sufficient properties for the creation of thickened cardiac tissue.

TL;DR: Indirect co-culture of pancreatic cancer cells with PSCs enhanced the spheroid-forming ability of cancer cells and induced the expression of cancer stem cell-related genes ABCG2, Nestin and LIN28, which suggested a novel role of P SCs as a part of the cancer stem Cell niche.

TL;DR: Internalization of citrate-coated and uncoated superparamagnetic iron oxide nanoparticles by human breast cancer (MCF-7) cells was verified by transmission electron microscopy imaging and metabolic and trypan blue assays manifested their excellent biocompatibility.

TL;DR: The results show that pretreating rat neonatal cardiomyocytes with NaHS, a H(2)S donor, reduced the levels of ROS during the hypoxia/reoxygenation (H/R) condition and inhibited mitochondrial complex IV activity and increased the activities of superoxide dismutases (SODs), including Mn-SOD and CuZn-S OD.

TL;DR: In this article, the frequency of CD4+ CXCR5+ T cells is increased in pSS patients and positively correlated with autoantibodies in the blood, and the concentration of Th17-like subsets was found to be significantly higher than in healthy controls.

TL;DR: The findings indicate that miR-320a suppresses the growth of colon cancer cells by directly targeting β-catenin, suggesting its application in prognosis prediction and cancer treatment.

TL;DR: It is demonstrated that miR-30 could negatively regulate the expression of Snail1 by direct targeting the predicted binding site in the 3'UTR of Snails1 mRNA and it was demonstrated that TGF-β1-induced hepatocyte migration was greatly suppressed in cells transfected with miR -30b mimics.

TL;DR: PTEN could be a possible downstream regulator of AMPK, and the AMPK-PTEN pathway might be important in the regulation of the inflammatory response in VSMCs.

TL;DR: This study demonstrates that the local oxygen environment can be manipulated in vitro to either stabilise a chondrogenic phenotype for use in cartilage repair therapies or to promote hypertrophy of cartilaginous grafts for endochondral bone repair strategies.

TL;DR: The phagocytosis of ox-LDL can induce human macrophages to secrete IL-1β by activating the NLRP3 inflammasome, and it is shown that ox- LDL can upregulate the expression of the pro-IL-1 β protein, thus priming IL- 1β secretion.

TL;DR: It is found that GLP-1 induced signal transducer and activator of transcription 3 (STAT3) activation and induces macrophage polarization toward the M2 phenotype, which may contribute to the protective effects of GLPs against diabetes and cardiovascular diseases.

TL;DR: Recent research progress on the regulation of miRNAs in bone biology is reviewed, with a particular focus on the miRNA-mediated control mechanisms of bone and cartilage formation.

TL;DR: The results suggest that ANRIL splicing variants play a role in coordinating tissue remodeling, by modulating the expression of genes involved in cell proliferation, apoptosis, extra-cellular matrix remodeling and inflammatory response to finally impact in the risk of cardiovascular disease and other pathologies.

TL;DR: It is demonstrated that upregulated miR-130a directly inhibited expression of tumor suppressor gene RUNX3, which resulted in activation of Wnt/β-catenin signaling and increased drug resistance, thus offering a new target for chemotherapy of HCC.

TL;DR: It is shown that siRNA-mediated DRP1 knockdown promoted accumulation of elongated mitochondria in HCT116 and SW480 human colon cancer cells and Surprisingly, DRp1 down-regulation led to decreased proliferation and increased apoptosis of these cells.

TL;DR: It is found that miR-124 overexpression markedly suppressed cell proliferation by inducing G1-phase cell-cycle arrest in vitro and plays an important role in inhibiting the tumorigenesis through targeting PIK3CA.

TL;DR: Time-of-drug addition studies reveal that T-705 exerts its activity at a time-point that coincides with onset of viral RNA synthesis, which is in line with the viral polymerase as the presumed target.

TL;DR: Results demonstrate that NOSH-aspirin has strong anti-cancer potential and merits further evaluation, and is the first NSAID based agent with such high degree of potency.

TL;DR: It is demonstrated that miR-25 promotes ESCC cell migration and invasion by suppressing CDH1 expression, which is a very important tumor metastasis suppressor.

TL;DR: It is found that depletion of cholesterol in MAMs with methyl-β-cyclodextrin (MβC) significantly increases the association between M AMs and mitochondria, whereas MβC saturated with cholesterol does not change the association.