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Yang Zhang
Researcher at The Chinese University of Hong Kong
Publications - 21
Citations - 1322
Yang Zhang is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Fibrosis & Endothelial dysfunction. The author has an hindex of 15, co-authored 20 publications receiving 1064 citations.
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Journal ArticleDOI
miR-29b as a therapeutic agent for angiotensin II-induced cardiac fibrosis by targeting TGF-β/Smad3 signaling.
TL;DR: In this paper, the role and therapeutic potential of miR-29 in a mouse model of hypertension induced by angiotensin II (AngII) was examined by using microRNA microarray, in situ hybridization, and real-time polymerase chain reaction.
Journal ArticleDOI
Inflammatory macrophages can transdifferentiate into myofibroblasts during renal fibrosis.
Xiao-Ming Meng,Shuang Wang,Xiao R. Huang,Chen Yang,Jun Xiao,Yang Zhang,Ka Fai To,David J. Nikolic-Paterson,Hui-Yao Lan +8 more
TL;DR: Findings provide substantial new data to support the postulate that macrophages can directly transdifferentiate into collagen-producing myofibroblasts in human and experimental kidney disease.
Journal ArticleDOI
TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis
Shuang Wang,Xiao-Ming Meng,Yee Yung Ng,Frank Y. Ma,Shuang Zhou,Yang Zhang,Chen Yang,Xiao R. Huang,Jun Xiao,Ying-Ying Wang,Shuk-Man Ka,Yong-Jiang Tang,Arthur C.K. Chung,Ka Fai To,David J. Nikolic-Paterson,Hui Y. Lan +15 more
TL;DR: It is demonstrated that bone marrow-derived fibroblasts originate from the monocyte/macrophage population via a process of MMT, which contributes to progressive renal tissue fibrosis and is regulated by TGF-β/Smad3 signalling.
Journal ArticleDOI
Uncoupling Protein-2 Protects Endothelial Function in Diet-Induced Obese Mice
Xiao Yu Tian,Wing Tak Wong,Aimin Xu,Ye Lu,Yang Zhang,Li Wang,Wai San Cheang,Yu Wang,Xiaoqiang Yao,Yu Huang +9 more
TL;DR: UCP2 preserves endothelial function through increasing nitric oxide bioavailability secondary to the inhibition of ROS production in the endothelium of obese diabetic mice.
Journal ArticleDOI
Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin f(2α) impairs endothelial function in renovascular hypertensive rats.
Xiao Yu Tian,Wing Tak Wong,Fung Ping Leung,Yang Zhang,Yi-Xiang J. Wang,Hung Kay Lee,Chi-Fai Ng,Zhen-Yu Chen,Xiaoqiang Yao,CL Au,Chi Wai Lau,Paul M. Vanhoutte,John P. Cooke,Yu Huang +13 more
TL;DR: These findings demonstrate the functional importance of oxidative stress, and that COX-2-derived PGF(2α) plays an important role in mediating endothelial dysfunction in RH.