F
Frank Y. Ma
Researcher at Monash Medical Centre
Publications - 56
Citations - 2632
Frank Y. Ma is an academic researcher from Monash Medical Centre. The author has contributed to research in topics: Kidney & Renal fibrosis. The author has an hindex of 29, co-authored 54 publications receiving 2196 citations. Previous affiliations of Frank Y. Ma include University of Otago & Royal Children's Hospital.
Papers
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Journal ArticleDOI
Monocyte chemoattractant protein-1-induced tissue inflammation is critical for the development of renal injury but not type 2 diabetes in obese db / db mice
Fiona Yf Chow,David J. Nikolic-Paterson,Frank Y. Ma,Elyce Ozols,Barrett J. Rollins,Gregory H Tesch +5 more
TL;DR: It is demonstrated that MCP-1 promotes type 2 diabetic renal injury but does not influence the development of obesity, insulin resistance or type 2 diabetes in db/db mice.
Journal ArticleDOI
TGF-β/Smad3 signalling regulates the transition of bone marrow-derived macrophages into myofibroblasts during tissue fibrosis
Shuang Wang,Xiao-Ming Meng,Yee Yung Ng,Frank Y. Ma,Shuang Zhou,Yang Zhang,Chen Yang,Xiao R. Huang,Jun Xiao,Ying-Ying Wang,Shuk-Man Ka,Yong-Jiang Tang,Arthur C.K. Chung,Ka Fai To,David J. Nikolic-Paterson,Hui Y. Lan +15 more
TL;DR: It is demonstrated that bone marrow-derived fibroblasts originate from the monocyte/macrophage population via a process of MMT, which contributes to progressive renal tissue fibrosis and is regulated by TGF-β/Smad3 signalling.
Journal ArticleDOI
The JNK Signaling Pathway in Renal Fibrosis
TL;DR: In conclusion, JNK signaling plays an integral role in several key mechanisms operating in renal fibrosis, and targeting of JNK enzymes has therapeutic potential for the treatment of fibrotic kidney diseases.
Journal ArticleDOI
A Pathogenic Role for c-Jun Amino-Terminal Kinase Signaling in Renal Fibrosis and Tubular Cell Apoptosis
Frank Y. Ma,Robert S Flanc,Gregory H Tesch,Yingjie Han,Robert C. Atkins,Brydon L. Bennett,Glenn C. Friedman,Jui-Hsiang Fan,David J. Nikolic-Paterson +8 more
TL;DR: This is the first study to demonstrate that JNK signaling plays a pathogenic role in renal fibrosis and tubular apoptosis, and JNK1 plays a nonredundant role in tubular cell apoptosis.
Journal ArticleDOI
TGF-β1-activated kinase-1 regulates inflammation and fibrosis in the obstructed kidney.
Frank Y. Ma,Greg H. Tesch,Elyce Ozols,Min Xie,Michael D. Schneider,David J. Nikolic-Paterson +5 more
TL;DR: TAK1 is established as a major upstream activator of JNK, p38, and NF-κB signaling in the obstructed kidney, and they define a pathologic role for TAK1 in renal inflammation and fibrosis.