Y
Yanhua H. Huang
Researcher at University of Pittsburgh
Publications - 70
Citations - 6038
Yanhua H. Huang is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Nucleus accumbens & Silent synapse. The author has an hindex of 32, co-authored 64 publications receiving 5227 citations. Previous affiliations of Yanhua H. Huang include Johns Hopkins University & Washington State University.
Papers
More filters
Journal ArticleDOI
β-Lactam antibiotics offer neuroprotection by increasing glutamate transporter expression
Jeffrey D. Rothstein,Sarjubhai Patel,Melissa R. Regan,Christine Haenggeli,Yanhua H. Huang,Dwight E. Bergles,Lin Jin,Margaret Dykes Hoberg,Svetlana Vidensky,Dorothy S. Chung,Shuy Vang Toan,Lucie I. Bruijn,Zao-Zhong Su,Pankaj Gupta,Paul B. Fisher +14 more
TL;DR: Using a blinded screen of 1,040 FDA-approved drugs and nutritionals, it is discovered that many β-lactam antibiotics are potent stimulators of GLT1 expression, and this action appears to be mediated through increased transcription of theGLT1 gene.
Journal ArticleDOI
Variations in Promoter Activity Reveal a Differential Expression and Physiology of Glutamate Transporters by Glia in the Developing and Mature CNS
Melissa R. Regan,Yanhua H. Huang,Yu Shin Kim,Margaret Dykes-Hoberg,Lin Jin,Andrew M. Watkins,Dwight E. Bergles,Jeffrey D. Rothstein +7 more
TL;DR: These studies of GLT-1 and GLAST promoter activity, protein expression, and glutamate uptake revealed a close correlation between transgenic reporter signals and uptake capacity, indicating that these mice provide the means to monitor the expression and regulation of glutamate transporters in situ.
Journal ArticleDOI
Regulation of the NMDA Receptor Complex and Trafficking by Activity-Dependent Phosphorylation of the NR2B Subunit PDZ Ligand
TL;DR: Results indicate that activity-dependent CK2 phosphorylation of the NR2B PDZ ligand regulates the interaction of NMDAR with PSD-95/SAP90 family proteins as well as surface N MDAR expression and may be a critical mechanism for modulating excitatory synaptic function and plasticity.
Journal ArticleDOI
Glutamate transporters bring competition to the synapse.
TL;DR: The diversity in synaptic morphology suggests a correspondingly rich diversity of GluT function in excitatory transmission, particularly in extrasynaptic NMDA receptors and metabotropic glutamate receptors.
Journal ArticleDOI
Bidirectional Modulation of Incubation of Cocaine Craving by Silent Synapse-Based Remodeling of Prefrontal Cortex to Accumbens Projections
Yao-Ying Ma,Brian Lee,Xiusong Wang,Chang-Yong Guo,Lei Liu,Ranji Cui,Yan Lan,Judith Joyce Balcita-Pedicino,Marina E. Wolf,Susan R. Sesack,Yavin Shaham,Oliver M. Schlüter,Yanhua H. Huang,Yan Dong +13 more
TL;DR: It is shown that silent synapse-based remodeling of the two major mPFC-to-NAc projections differentially regulated the progressive increase in cue-induced cocaine seeking after withdrawal (incubation of cocaine craving), which may provide substrates for utilizing endogenous antirelapse mechanisms to reduce cocaine relapse.