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Yanjun Li
Researcher at Nankai University
Publications - 14
Citations - 952
Yanjun Li is an academic researcher from Nankai University. The author has contributed to research in topics: Mitochondrion & Mitophagy. The author has an hindex of 7, co-authored 8 publications receiving 508 citations. Previous affiliations of Yanjun Li include Chinese Academy of Sciences.
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Journal ArticleDOI
Mitophagy receptor FUNDC1 regulates mitochondrial dynamics and mitophagy.
Ming Chen,Ziheng Chen,Yueying Wang,Zheng Tan,Chongzhuo Zhu,Yanjun Li,Zhe Han,Linbo Chen,Ruize Gao,Lei Liu,Quan Chen +10 more
TL;DR: The data suggest that FUNDC1 regulates both mitochondrial fission or fusion and mitophagy and mediates the “coupling” across the double membrane for mitochondrial dynamics and quality control.
Journal ArticleDOI
STING directly activates autophagy to tune the innate immune response.
Dong Liu,Hao Wu,Chenguang Wang,Yanjun Li,Huabin Tian,Sami Siraj,Sami Siraj,Sheikh Arslan Sehgal,Xiaohui Wang,Jun Wang,Yingli Shang,Zhengfan Jiang,Lei Liu,Quan Chen,Quan Chen +14 more
TL;DR: The results thus uncover dual functions of STING in activating the immune response and autophagy, and suggest that STING is involved in ensuring a measured innate immune response.
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Mitochondrial E3 ligase MARCH5 regulates FUNDC1 to fine‐tune hypoxic mitophagy
Ziheng Chen,Lei Liu,Qi Cheng,Yanjun Li,Hao Wu,Weilin Zhang,Yueying Wang,Sheikh Arslan Sehgal,Sheikh Arslan Sehgal,Sami Siraj,Sami Siraj,Xiaohui Wang,Jun Wang,Yushan Zhu,Quan Chen +14 more
TL;DR: It is found that the mitochondrial E3 ligase MARCH5, but not Parkin, plays a role in regulating hypoxia‐induced mitophagy by ubiquitylating and degrading FUNDC1.
Journal ArticleDOI
FUN14 Domain-Containing 1-Mediated Mitophagy Suppresses Hepatocarcinogenesis by Inhibition of Inflammasome Activation in Mice.
Wenhui Li,Yanjun Li,Sami Siraj,Sami Siraj,Haojie Jin,Yuyuan Fan,Xin-Rong Yang,Xiao-Wu Huang,Xiaohui Wang,Jun Wang,Lei Liu,Lei Du,Quan Chen,Quan Chen +13 more
TL;DR: A mechanistic link between mitophagic modulation of inflammatory response and tumorigenesis is described, which implies that FUNDC1‐mediated mitophagy and its related inflammatory response may represent a therapeutic target for liver cancer.
Journal ArticleDOI
A mitochondrial FUNDC1/HSC70 interaction organizes the proteostatic stress response at the risk of cell morbidity.
Yanjun Li,Yanhong Xue,Xiaojun Xu,Guopeng Wang,Yiqun Liu,Hao Wu,Wenhui Li,Yueying Wang,Ziheng Chen,Weilin Zhang,Yushan Zhu,Wei Ji,Tao Xu,Tao Xu,Lei Liu,Quan Chen,Quan Chen +16 more
TL;DR: It is suggested that human mitochondria organize cellular proteostatic response at the risk of their own malfunction and cell lethality.