Michael F. Wempe

TL;DR: LAT1-mediated [(14)C]phenylalanine uptake was strongly inhibited in a competitive manner by aromatic-amino acid derivatives including L-dopa, alpha-methyldopa, melphalan, triiodothyronine, and thyroxine, whereas phenylalanin methyl ester, N-methyl phenylAlanine, dopamine, tyramine, carbidopa, and droxidopa did not inhibit LAT1- mediated uptake.

TL;DR: Transport studies indicate that ATPase inhibition is an essential factor in the inhibitory mechanism of TPGS 1000 on cellular efflux pumps.

TL;DR: This study examined the effect of glucan structure on recognition and binding by murine recombinant Dectin-1 with a library of natural product and synthetic (1→3)-β/(1→6)-β-glucans as well as nonglucan polymers and found that glucan derived from a saprophytic yeast was recognized with higher affinity than glucanderived from the pathogen Candida albicans.

TL;DR: A convenient new method, which is referred to as "in-source multiple reaction monitoring" (IS-MRM), for detecting GPCho's during LC-MS/MS method development and probe ionization matrix effects in plasma samples.

TL;DR: KYT‐0353 appears to have potential as a novel anti‐tumor agent, presumably via selective in vivol‐type amino acid transporter 1 inhibition, according to in vitro and in vivo studies.