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Yannick Morel
Researcher at French Institute of Health and Medical Research
Publications - 12
Citations - 1531
Yannick Morel is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Gene expression & Promoter. The author has an hindex of 11, co-authored 12 publications receiving 1464 citations. Previous affiliations of Yannick Morel include University of Paris.
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Journal ArticleDOI
Repression of gene expression by oxidative stress.
Yannick Morel,Robert Barouki +1 more
TL;DR: The alteration of several physiological functions resulting from oxidative-stress-mediated inhibition of gene transcription are described and the repressive oxidative modulation of various transcription factors elicited by ROS is focused on.
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Dietary Polyphenols Increase Paraoxonase 1 Gene Expression by an Aryl Hydrocarbon Receptor-Dependent Mechanism
TL;DR: Observations provide a molecular mechanism for the regulation of the cardioprotective enzyme PON-1 by polyphenols and suggest also that AhR ligands may differentially regulate gene expression depending on the DNA target sequence.
Journal ArticleDOI
Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress. Critical contribution of nuclear factor 1
Yannick Morel,Robert Barouki +1 more
TL;DR: It is shown here that the human cytochrome P450 1A1 (CYP1A1) is down-regulated at the transcriptional level by oxidative stress, which accounts, at least partially, for the regulation of CYP1A 1 gene expression.
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Repression of cytochrome P450 1A1 gene expression by oxidative stress: mechanisms and biological implications.
Robert Barouki,Yannick Morel +1 more
TL;DR: The regulatory mechanisms that limit the induction of the CYP1A1 gene are discussed, which suggest that more attention should be given to transactivating domains that may represent biologically relevant redox targets of cellular signaling.
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Opposite regulation of the human paraoxonase-1 gene PON-1 by fenofibrate and statins.
TL;DR: Transient and stable transfection assays in HuH7 cells indicated that the modulation of the mRNA and enzymatic activity levels could be accounted for by the regulation of the PON-1 gene promoter activity by these drugs.