Yanxi Ji

TL;DR: This work identified a novel VSR from coronaviruses, a group of medically important mammalian viruses including Severe acute respiratory syndrome coronavirus, and showed that the nucleocapsid protein (N protein) of coronviruses suppresses RNAi triggered by either short hairpin RNAs or small interfering RNAs in mammalian cells.

TL;DR: Oral administration of ATV006 reduced viral loads and alleviated lung damage when administered prophylactically and therapeutically to K18-hACE2 mice challenged with the Delta variant of SARS-CoV-2.

TL;DR: This study characterized a ubiquitin‐associated (UBA) domain in the N‐terminal region of Cezanne and proved its activity to bind Lys63 polyubiquitin chain and shed light on the molecular mechanism of negative regulation of NF‐κB activation by CezAnne.

TL;DR: It is demonstrated that mutations in the regions corresponding to the sequences of the probes and 3’-end of primers have a significant impact on qPCR detection efficiency, and that the G28916T mutation of the N gene accounts for 78.78% sequenced genomes of Delta variant.

TL;DR: Systematic comparisons of the mouse models that express the human angiotensin converting enzyme 2 (hACE2) revealed differences in the distribution of lesions and the characteristics of pneumonia induced, which may help in better understanding the pathogenic process of SARS‐CoV‐2 infection and aiding in the development of effective medications and prophylactic treatments.