L
Liu Cao
Researcher at Sun Yat-sen University
Publications - 7
Citations - 1011
Liu Cao is an academic researcher from Sun Yat-sen University. The author has contributed to research in topics: Virus & Signal transduction. The author has an hindex of 5, co-authored 7 publications receiving 701 citations. Previous affiliations of Liu Cao include Wuhan University.
Papers
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Journal ArticleDOI
Transcriptomic characteristics of bronchoalveolar lavage fluid and peripheral blood mononuclear cells in COVID-19 patients.
Yong Xiong,Yuan Liu,Liu Cao,Dehe Wang,Ming Guo,Ao Jiang,Dong Guo,Wenjia Hu,Jiayi Yang,Zhidong Tang,Honglong Wu,Yongquan Lin,Meiyuan Zhang,Qi Zhang,Mang Shi,Yingle Liu,Yu Zhou,Ke Lan,Yu Chen +18 more
TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.
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A Convenient and Biosafe Replicon with Accessory Genes of SARS-CoV-2 and Its Potential Application in Antiviral Drug Discovery.
Yun-Yun Jin,Hanwen Lin,Liu Cao,Wei-Chen Wu,Yanxi Ji,Liubing Du,Jiang Yiling,Yanchun Xie,Kuijie Tong,Fan Xing,Fuxiang Zheng,Mang Shi,Ji-An Pan,Xiaoxue Peng,Deyin Guo +14 more
TL;DR: In this paper, a reverse genetics system of SARS-CoV-2 was constructed by assembling the viral cDNA in a bacterial artificial chromosome (BAC) vector with deletion of the spike (S) gene.
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P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus
Liu Cao,Yanxi Ji,Yanxi Ji,Lanyi Zeng,Qianyun Liu,Zhen Zhang,Shuting Guo,Xiaolong Guo,Yongjia Tong,Xiaolu Zhao,Chunmei Li,Yu Chen,Deyin Guo +12 more
TL;DR: The results reveal that the interferon-inducible p200 family proteins such as IFI204 could also negatively regulate the IRF7-mediated type I interferons response after RNA virus infection to avoid unnecessary host damage from hyper-inflammatory responses.
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Live attenuated coronavirus vaccines deficient in N7-Methyltransferase activity induce both humoral and cellular immune responses in mice.
Zhen Zhang,Qianyun Liu,Ying Sun,Jiali Li,Jiejie Liu,Ruangang Pan,Liu Cao,Xianying Chen,Yingjian Li,Yuzhen Zhang,Ke Xu,Deyin Guo,Li Zhou,Ke Lan,Yu Chen +14 more
TL;DR: Wang et al. as mentioned in this paper showed that N7-MTase of CoVs can be an ideal target for designing live attenuated vaccines, which can provide full protection against the challenge of a lethal-dose of MHV-A59.
Journal ArticleDOI
The N-terminal ubiquitin-associated domain of Cezanne is crucial for its function to suppress NF-κB pathway.
Yanxi Ji,Liu Cao,Lanyi Zeng,Zhen Zhang,Qiaoqiao Xiao,Penglin Guan,Shiyou Chen,Yu Chen,Min Wang,Deyin Guo +9 more
TL;DR: This study characterized a ubiquitin‐associated (UBA) domain in the N‐terminal region of Cezanne and proved its activity to bind Lys63 polyubiquitin chain and shed light on the molecular mechanism of negative regulation of NF‐κB activation by CezAnne.