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Yaodong Zhu
Researcher at Yangzhou University
Publications - 11
Citations - 218
Yaodong Zhu is an academic researcher from Yangzhou University. The author has contributed to research in topics: Cancer & Apoptosis. The author has an hindex of 7, co-authored 8 publications receiving 176 citations.
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Journal ArticleDOI
Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma
Yaodong Zhu,Yanqing Liu,Yayun Qian,Xiaojun Dai,Ling Yang,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +7 more
TL;DR: It is suggested that COE inhibits the EMT by suppressing the expression of HSP27, correlating with inhibition of NF-κB/Snail signal pathways in SGC-7901 cells, and may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.
Journal ArticleDOI
Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells
Lin Yang,Yanqing Liu,Mei Wang,Yayun Qian,Xiaojun Dai,Yaodong Zhu,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +8 more
TL;DR: It is demonstrated that both autophagy and apoptosis were activated during COE treatment of HT-29 cells, and that COE-induced autophagic decreases the viability ofHT- 29 cells via a mechanism that may depend on the PI3K/Akt/mTOR/p70S6K signaling pathway.
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Anti-invasive effects of celastrol in hypoxia-induced fibroblast-like synoviocyte through suppressing of HIF-1α/CXCR4 signaling pathway.
Guoqing Li,Dan Liu,Yu Zhang,Yayun Qian,Yaodong Zhu,Shiyu Guo,Masataka Sunagawa,Tadashi Hisamitsu,Yanqing Liu +8 more
TL;DR: The results indicate that celastrol inhibits hypoxia-induced migration and invasion via suppression of HIF-1α mediated CXCR4 expression in FLSs under hypoxic conditions.
Journal ArticleDOI
Antimetastatic Effects of Celastrus orbiculatus on Human Gastric Adenocarcinoma by Inhibiting Epithelial–Mesenchymal Transition and NF-κB/Snail Signaling Pathway:
Yaodong Zhu,Yanqing Liu,Yayun Qian,Xiaojun Dai,Lin Yang,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +7 more
TL;DR: Findings provided new evidence that COE is an effective inhibitor of metastatic potential of SGC-7901 cells through suppression of EMT and NF-κB/Snail signal pathway.
Journal ArticleDOI
Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells.
Hua Zhang,Yayun Qian,Yanqing Liu,Guoqing Li,Pingfang Cui,Yaodong Zhu,Hui Ma,Xue Ji,Shiyu Guo,Hisamits Tadashi +9 more
TL;DR: COE induces mitochondrial-mediated, caspase-dependent apoptosis in HCCLM6 cells, which might be attributed to the activation of mitogen-activated protein kinase (MAPK) and inhibition of Akt signaling pathways, which suggest that COE may be a potential treatment for human hepatocellular carcinoma.