Celastrus orbiculatus extract induces mitochondrial-mediated apoptosis in human hepatocellular carcinoma cells.
Hua Zhang,Yayun Qian,Yanqing Liu,Guoqing Li,Pingfang Cui,Yaodong Zhu,Hui Ma,Xue Ji,Shiyu Guo,Hisamits Tadashi +9 more
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TLDR
COE induces mitochondrial-mediated, caspase-dependent apoptosis in HCCLM6 cells, which might be attributed to the activation of mitogen-activated protein kinase (MAPK) and inhibition of Akt signaling pathways, which suggest that COE may be a potential treatment for human hepatocellular carcinoma.About:
This article is published in Journal of Traditional Chinese Medicine.The article was published on 2012-12-01 and is currently open access. It has received 29 citations till now. The article focuses on the topics: Protein kinase B & Celastrus orbiculatus.read more
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Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition.
Lorena Avila-Carrasco,Pedro L. Majano,José Antonio Sánchez-Tomero,Rafael Selgas,Manuel López-Cabrera,Abelardo Aguilera,Guadalupe González Mateo +6 more
TL;DR: A systematic review of effective natural plant compounds and their extract that modulates the pathological EMT or its deleterious effects, through acting on different cellular signal transduction pathways both in vivo and in vitro is introduced.
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Research on the efficacy of Celastrus Orbiculatus in suppressing TGF-β1-induced epithelial-mesenchymal transition by inhibiting HSP27 and TNF-α-induced NF-κB/Snail signaling pathway in human gastric adenocarcinoma
Yaodong Zhu,Yanqing Liu,Yayun Qian,Xiaojun Dai,Ling Yang,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +7 more
TL;DR: It is suggested that COE inhibits the EMT by suppressing the expression of HSP27, correlating with inhibition of NF-κB/Snail signal pathways in SGC-7901 cells, and may be considered a novel anti-cancer agent for the treatment of metastasis in gastric cancer.
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Celastrus orbiculatus extract triggers apoptosis and autophagy via PI3K/Akt/mTOR inhibition in human colorectal cancer cells
Lin Yang,Yanqing Liu,Mei Wang,Yayun Qian,Xiaojun Dai,Yaodong Zhu,Jue Chen,Shiyu Guo,Tadashi Hisamitsu +8 more
TL;DR: It is demonstrated that both autophagy and apoptosis were activated during COE treatment of HT-29 cells, and that COE-induced autophagic decreases the viability ofHT- 29 cells via a mechanism that may depend on the PI3K/Akt/mTOR/p70S6K signaling pathway.
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Traditional uses, secondary metabolites, and pharmacology of Celastrus species - a review.
TL;DR: Plants of genus Celastrus have been confirmed to show a strong potential for therapeutic and health-maintaining effects, in light of their long traditional use and the phytochemical and pharmacological studies summarized here.
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Ginsenoside Rg3 inhibits colon cancer cell migration by suppressing nuclear factor kappa B activity
TL;DR: Ginsenoside Rg3 has a strong antitumor migration capability by suppressing NF-κB activity and expression of NF-σκB-regulated gene products and could be a good adjuvant for colon cancer patients during the course of chemotherapy.
References
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