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Yaoxue Yin
Researcher at Nanjing Medical University
Publications - 5
Citations - 147
Yaoxue Yin is an academic researcher from Nanjing Medical University. The author has contributed to research in topics: Oocyte & PI3K/AKT/mTOR pathway. The author has an hindex of 2, co-authored 4 publications receiving 99 citations.
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Journal ArticleDOI
Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice
Jing Guo,Teng Zhang,Yueshuai Guo,Tao Sun,Hui Li,Xiaoyun Zhang,Hong Yin,Guangyi Cao,Yaoxue Yin,Hao Wang,Lanying Shi,Xuejiang Guo,Jiahao Sha,John J. Eppig,You-Qiang Su +14 more
TL;DR: It is shown that conditional knockout (cKO) of Mtor in either primordial or growing oocytes caused infertility but differentially affected oocyte quality, granulosa cell fate, and follicular development.
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Oocyte-dependent activation of MTOR in cumulus cells controls the development and survival of cumulus-oocyte complexes.
Jing Guo,Lanying Shi,Xuhong Gong,Mengjie Jiang,Yaoxue Yin,Xiaoyun Zhang,Hong Yin,Hui Li,Chihiro Emori,Koji Sugiura,John J. Eppig,You-Qiang Su +11 more
TL;DR: By suppressing Ddit4l expression, thereby enabling MTOR activation in cumulus cells, oocytes promote cumulus cell development and survival, which in turn ensures the production of functionally normal eggs.
Journal ArticleDOI
Echinoderm Microtubule Associated Protein Like 1 Is Indispensable for Oocyte Spindle Assembly and Meiotic Progression in Mice
Hong Yin,Teng Zhang,Hao Wang,Xin Hu,Xuan Hou,Xianbao Fang,Yaoxue Yin,Hui Li,Lanying Shi,You-Qiang Su +9 more
TL;DR: This article showed that EML1-KD impairs the recruitment of γ-tubulin and pericentrin to the spindle poles, as well as the attachment of kinetochores to microtubules and the proper inactivation of spindle assembly checkpoint at metaphase I (MI).
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MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in mice
TL;DR: Results suggest that activation of MTOR in cumulus cells contributes to the maintenance of oocyte meiotic arrest before the LH surge, and proposes that MTOR is an essential mediator of the bi-directional communication between the oocyte and granulosa cells that regulates the development and function of both compartments.