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Koji Sugiura

Researcher at University of Tokyo

Publications -  77
Citations -  8132

Koji Sugiura is an academic researcher from University of Tokyo. The author has contributed to research in topics: Oocyte & Germinal vesicle. The author has an hindex of 29, co-authored 74 publications receiving 7466 citations.

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Journal ArticleDOI

The Transcriptional Landscape of the Mammalian Genome

Piero Carninci, +197 more
- 02 Sep 2005 - 
TL;DR: Detailed polling of transcription start and termination sites and analysis of previously unidentified full-length complementary DNAs derived from the mouse genome provide a comprehensive platform for the comparative analysis of mammalian transcriptional regulation in differentiation and development.
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Granulosa cell ligand NPPC and its receptor NPR2 maintain meiotic arrest in mouse oocytes.

TL;DR: NPPC (natriuretic peptide precursor type C), produced by mural granulosa cells, and its receptor NPR2, a guanylyl cyclase expressed by cumulus cells, together promote cGMP production by Cumulus cells and are thus essential for maintaining meiotic arrest in mouse oocytes.
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Oocyte regulation of metabolic cooperativity between mouse cumulus cells and oocytes: BMP15 and GDF9 control cholesterol biosynthesis in cumulus cells

TL;DR: The results indicate that mouse oocytes are deficient in synthesizing cholesterol and require cumulus cells to provide products of the cholesterol biosynthetic pathway, and oocyte-derived paracrine factors, particularly, BMP15 and GDF9, promote cholesterol biosynthesis incumulus cells, probably as compensation for oocyte deficiencies in cholesterol production.
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Mouse Oocyte Control of Granulosa Cell Development and Function: Paracrine Regulation of Cumulus Cell Metabolism

TL;DR: Oocytes outsource metabolic functions to cumulus cells to compensate for oocyte metabolic deficiencies, and influence granulosa cell development mainly by secretion of paracrine factors, although juxtacrine signals probably also participate.
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Oocyte control of metabolic cooperativity between oocytes and companion granulosa cells: energy metabolism.

TL;DR: Mouse oocytes control the intercellular metabolic cooperativity between cumulus cells and oocytes needed for energy production by granulosa cells and required for oocyte and follicular development.