Yapu Zhao

TL;DR: A novel function of Vγ4 γδ T cells is demonstrated in mediating a protective effect against Con A-induced fulminant hepatitis through negatively regulating function of NKT cells in an IL-17A–dependent manner, and transferring Vγ 4 γ Δ T cells may provide a novel therapeutic approach for this devastating liver disease.

TL;DR: This very uniform hybrid Alum particulate system could have important application as a vaccine carrier to stimulate humoral and cellular immune responses at the same time.

TL;DR: Treatment with β-glucan particles significantly prevented the growth of implanted EG7-OVA tumors in a prophylactic and pre-established tumor model, suggesting that this strategy may be able to be utilized as a promising platform for cancer immunotherapy.

TL;DR: Patients with activated NF-κB signaling should be given priority for enrollment in future phase II clinical trials, as the underlying mechanisms of a new orphan drug, ACT001, significantly suppressed glioma cell proliferation and induced apoptosis and cell cycle arrest in vitro.

TL;DR: A population of IL‐10‐producing CD8+ Tregs induced by IL‐4 and mediated by Cdkn2a is defined, indicating a critical role of this population of CD8- T cells in regulatory immune responses.