S
Susan M. Kaech
Researcher at Salk Institute for Biological Studies
Publications - 189
Citations - 34167
Susan M. Kaech is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Cytotoxic T cell & T cell. The author has an hindex of 75, co-authored 174 publications receiving 29315 citations. Previous affiliations of Susan M. Kaech include University of Melbourne & Stanford University.
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Journal ArticleDOI
Lineage relationship and protective immunity of memory CD8 T cell subsets.
E. John Wherry,Volker Teichgräber,Todd C. Becker,David Masopust,Susan M. Kaech,Rustom Antia,Ulrich H. von Andrian,Rafi Ahmed +7 more
TL;DR: It is proposed that TCM and TEM do not necessarily represent distinct subsets, but are part of a continuum in a linear naive → effector → TEM → TCM differentiation pathway.
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Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells
TL;DR: Increased expression of the interleukin 7 receptor α-chain (IL-7Rα) identifies the effector CD8 T cells that will differentiate into memory cells, and this marker may be useful in predicting the number of memory T cells generated after infection or immunization.
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Molecular Signature of CD8+ T Cell Exhaustion during Chronic Viral Infection
E. John Wherry,Sang Jun Ha,Susan M. Kaech,W. Nicholas Haining,Surojit Sarkar,Vandana Kalia,Shruti Subramaniam,Joseph N. Blattman,Daniel L. Barber,Rafi Ahmed +9 more
TL;DR: T cell exhaustion was progressive, and gene-expression profiling indicated that T cell exhaustion and anergy were distinct processes, which provides a framework for designing rational immunotherapies during chronic infections.
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Effector and memory T-cell differentiation: implications for vaccine development
TL;DR: The signals required for commitment to this programme of development and the factors that might influence its progression are discussed and models of the pathways of effector and memory T-cell differentiation are discussed.
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Inflammation directs memory precursor and short-lived effector CD8(+) T cell fates via the graded expression of T-bet transcription factor.
Nikhil S. Joshi,Weiguo Cui,Anmol Chandele,Heung Kyu Lee,David Urso,James Hagman,Laurent Gapin,Susan M. Kaech +7 more
TL;DR: A mechanism by which the innate immune system sets the relative amounts of a lineage-determining transcription factor in activated CD8(+) T cells and regulates their memory cell potential is elucidated.