Puyue Wang

TL;DR: Let-7g is identified as a unique member of the let-7 miRNA family that can serve as a prognostic biomarker in breast cancer and a paradigm used by specific signaling molecules via let- 7g to cooperatively promote breast cancer invasion and metastasis is proposed.

TL;DR: It is determined that IFN-γ and perforin are critical elements in the Vγ4-mediated antitumor immune response, and a protective role of activated Vγ2 and Vγ1 γδ T cells is identified, with possible implications for tumor immune therapy.

TL;DR: A unique model for studying the pathology of CD4+ T cell–mediated liver injury is provided and a novel function of DC‐derived p28 on ConA‐induced fulminant hepatitis is revealed through regulation of the intrinsic ability for IFN‐γ production by CD4+.

TL;DR: The results established for the first time a negative regulatory role of Vγ1 γδ T cells in Vγ4 γ´ T cell-mediated antitumor immunity through cell contact-independent and IL-4–mediated mechanisms.

TL;DR: A novel function of Vγ4 γδ T cells is demonstrated in mediating a protective effect against Con A-induced fulminant hepatitis through negatively regulating function of NKT cells in an IL-17A–dependent manner, and transferring Vγ 4 γ Δ T cells may provide a novel therapeutic approach for this devastating liver disease.