J
Jeffrey N. Bruce
Researcher at Columbia University
Publications - 259
Citations - 13763
Jeffrey N. Bruce is an academic researcher from Columbia University. The author has contributed to research in topics: Glioma & Medicine. The author has an hindex of 57, co-authored 238 publications receiving 11337 citations. Previous affiliations of Jeffrey N. Bruce include NewYork–Presbyterian Hospital & Columbia University Medical Center.
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Journal ArticleDOI
NovoTTF-100A versus physician’s choice chemotherapy in recurrent glioblastoma: A randomised phase III trial of a novel treatment modality
Roger Stupp,Eric T. Wong,Andrew A. Kanner,David M. Steinberg,Herbert H. Engelhard,Volkmar Heidecke,Eilon D. Kirson,Sophie Taillibert,Frank Liebermann,Vladimír Dbalý,Zvi Ram,J. Lee Villano,Nikolai G. Rainov,Uri Weinberg,David Schiff,Lara Kunschner,Jeffrey J. Raizer,Jérôme Honnorat,Andrew E. Sloan,Mark G. Malkin,Joseph Landolfi,F. Payer,Maximilian Mehdorn,Robert J. Weil,Susan C. Pannullo,Manfred Westphal,Martin Smrčka,Lawrence S. Chin,Herwig Kostron,Silvia Hofer,Jeffrey N. Bruce,Rees Cosgrove,Nina Paleologous,Yoram Palti,Philip H. Gutin +34 more
TL;DR: No improvement in overall survival was demonstrated, however efficacy and activity with this chemotherapy-free treatment device appears comparable to chemotherapy regimens that are commonly used for recurrent glioblastoma.
Journal ArticleDOI
Promotion of tissue inflammation by the immune receptor Tim-3 expressed on innate immune cells.
Ana C. Anderson,David E. Anderson,Lisa Bregoli,William Hastings,Nasim Kassam,Charles Lei,Rucha Chandwaskar,Jozsef Karman,Ee W Su,Mitsuomi Hirashima,Jeffrey N. Bruce,Lawrence P. Kane,Vijay K. Kuchroo,David A. Hafler +13 more
TL;DR: It is found that Tim-3 is constitutively expressed on cells of the innate immune system in both mice and humans, and that it can synergize with Toll-like receptors and can either promote or terminate TH1 immunity.
Journal Article
Somatic mutations of PTEN in glioblastoma multiforme.
Steven I. Wang,Janusz Puc,Jing Li,Jeffrey N. Bruce,Paul Cairns,David Sidransky,Ramon Parsons +6 more
TL;DR: PTEN appears to be the major target of inactivation on chromosome 10q in glioblastoma multiforme, with loss of heterozygosity observed in 25 of 34 cases.
Journal ArticleDOI
Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Junfei Zhao,Andrew X. Chen,Robyn D. Gartrell,Andrew M. Silverman,Luis Aparicio,Tim Chu,Darius Bordbar,David Shan,Jorge Samanamud,Aayushi Mahajan,Ioan Filip,Rose Orenbuch,Morgan Goetz,Jonathan T. Yamaguchi,Michael Cloney,Craig Horbinski,Rimas V. Lukas,Jeffrey Raizer,Ali I Rae,Jinzhou Yuan,Peter Canoll,Jeffrey N. Bruce,Yvonne M. Saenger,Peter A. Sims,Fabio M. Iwamoto,Adam M. Sonabend,Raul Rabadan +26 more
TL;DR: This study shows that clinical response to anti-PD-1 immunotherapy in GBM is associated with specific molecular alterations, immune expression signatures, and immune infiltration that reflect the tumor’s clonal evolution during treatment.
Journal ArticleDOI
Human pineal physiology and functional significance of melatonin
M. Mila Macchi,Jeffrey N. Bruce +1 more
TL;DR: A rapidly expanding literature attests to the involvement of melatonin in immune function, with high levels promoting and low levels suppressing a number of immune system parameters.