Y
Yasuhito Yuasa
Researcher at Tokyo Medical and Dental University
Publications - 168
Citations - 9039
Yasuhito Yuasa is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 51, co-authored 165 publications receiving 8679 citations. Previous affiliations of Yasuhito Yuasa include Gunma University & University of Tokyo.
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Journal Article
Germ-line mutation of the hMSH6/GTBP gene in an atypical hereditary nonpolyposis colorectal cancer kindred
Yoshimitsu Akiyama,Hisayoshi Sato,Toshio Yamada,Hiromi Nagasaki,Atsuo Tsuchiya,Rikiya Abe,Yasuhito Yuasa +6 more
TL;DR: Somatic mutations of hMSH6 were observed in three colorectal tumors from the patient, indicating two-hit inactivation, and microsatellite instabilities at mononucleotide repeats were detected in all three tumors, suggesting that h MSH6 is responsible for tumorigenesis in atypical HNPCC.
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Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene.
Yasuhito Yuasa,Shiv Srivastava,Claire Y. Dunn,Johng S. Rhim,E. Premkumar Reddy,Stuart A. Aaronson +5 more
TL;DR: The transforming gene of a human lung carcinoma-derived cell line, Hs242, has been cloned in biologically active form, and identified as c-bas/has, which results in the substitution of leucine for glutamine as amino acid 61 of the predicted protein.
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Control of gut differentiation and intestinal-type gastric carcinogenesis.
TL;DR: Inappropriate activation of intestine-specific transcription factors could contribute to the occurrence of the intestinal-type cancer of the stomach.
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GATA-4 and GATA-5 Transcription Factor Genes and Potential Downstream Antitumor Target Genes Are Epigenetically Silenced in Colorectal and Gastric Cancer
Yoshimitsu Akiyama,D. Neil Watkins,Hiromu Suzuki,Kam Wing Jair,Manon van Engeland,Manon van Engeland,Manel Esteller,Hidekazu Sakai,Chun Yan Ren,Yasuhito Yuasa,James G. Herman,Stephen B. Baylin +11 more
TL;DR: It is shown that in colorectal cancer (CRC) and gastric cancer promoter hypermethylation and transcriptional silencing are frequent for GATA-4 and -5 but are never seen for Gata-6, which could indicate that epigenetic silencing of the involved genes provides a summated contribution to tumor progression.
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Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression
TL;DR: It is suggested that CDX2, but not CDX1, interacts with the M UC2 promoter and activates MUC2 transcription, and plays an important role in the differentiation of goblet cells.