D. Neil Watkins

TL;DR: A wide range of digestive tract tumours, including most of those originating in the oesophagus, stomach, biliary tract and pancreas, but not in the colon, display increased Hh pathway activity, which is suppressible by cyclopamine, a Hh pathways antagonist.

TL;DR: It is proposed that some types of SCLC might recapitulate a critical, Hh-regulated event in airway epithelial differentiation, and a common lethal malignancy that may respond to pharmacological blockade of the Hh signalling pathway is identified.

TL;DR: It is hypothesized that cell chromatin patterns and transient silencing of these important regulatory genes in stem or progenitor cells may leave these genes vulnerable to aberrant DNA hypermethylation and heritable gene silencing during tumor initiation and progression.

TL;DR: It is shown that restoration of SFRP function in colorectal cancer cells attenuates WNT signaling even in the presence of downstream mutations, and that the epigenetic loss of SfrP function occurs early in coloresceptic cancer progression and may thus provide constitutive W NT signaling that is required to complement downstream mutations in the evolution of coloreCTal cancer.

TL;DR: This compound caused regression of murine tumor allografts in vivo and induced rapid death of cells from freshly resected human medulloblastomas, but not from other brain tumors, thus establishing a specific role for Hh pathway activity in medullOBlastoma growth.