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Yasuki Higashimura
Researcher at Ishikawa Prefectural University
Publications - 70
Citations - 1616
Yasuki Higashimura is an academic researcher from Ishikawa Prefectural University. The author has contributed to research in topics: Colitis & Gut flora. The author has an hindex of 16, co-authored 66 publications receiving 1165 citations. Previous affiliations of Yasuki Higashimura include Kyoto Prefectural University of Medicine & Osaka Prefecture University.
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Heme oxygenase-1 and anti-inflammatory M2 macrophages.
TL;DR: The present current evidence indicates that HO-1 induction mediated by multiple pathways can drive the phenotypic shift to M2 macrophages and suggests that HO -1 induction in macrophage is a potential therapeutic approach to immunomodulation in widely diverse human diseases.
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Glyceraldehyde-3-phosphate dehydrogenase enhances transcriptional activity of androgen receptor in prostate cancer cells.
Naoki Harada,Ryoko Yasunaga,Yasuki Higashimura,Ryoichi Yamaji,Katsumi Fujimoto,Joel Moss,Hiroshi Inui,Yoshihisa Nakano +7 more
TL;DR: GAPDH functions as a coactivator with high selectivity for AR and enhances AR transactivation independent of its glycolytic activity, and data suggest that formation of a GAPDH·AR complex in the cytoplasm rather than nucleus is essential for GAPDh to enhance AR trans activation.
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Up-regulation of glyceraldehyde-3-phosphate dehydrogenase gene expression by HIF-1 activity depending on Sp1 in hypoxic breast cancer cells.
Yasuki Higashimura,Yoshito Nakajima,Ryoichi Yamaji,Naoki Harada,Futoshi Shibasaki,Yoshihisa Nakano,Hiroshi Inui +6 more
TL;DR: Results indicate that in MCF-7 cells, the activation of HIF-1 on the novel HRE contributes to the breast cancer-specific hypoxic induction of GAPDH gene expression and absolutely depends on the presence of Sp 1 on the GC-box.
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Green tea polyphenol (epigallocatechin-3-gallate) improves gut dysbiosis and serum bile acids dysregulation in high-fat diet-fed mice.
Chihiro Ushiroda,Yuji Naito,Tomohisa Takagi,Kazuhiko Uchiyama,Katsura Mizushima,Yasuki Higashimura,Zenta Yasukawa,Tsutomu Okubo,Ryo Inoue,Akira Honda,Yasushi Matsuzaki,Yoshito Itoh +11 more
TL;DR: It is suggested that EGCG could alter bile acid metabolism, especially taurine deconjugation, and suppress fatty liver disease by improving the intestinal luminal environment.
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Protective effect of agaro-oligosaccharides on gut dysbiosis and colon tumorigenesis in high-fat diet-fed mice
Yasuki Higashimura,Yuji Naito,Tomohisa Takagi,Kazuhiko Uchiyama,Katsura Mizushima,Chihiro Ushiroda,Hiromu Ohnogi,Yoko Kudo,Madoka Yasui,Seina Inui,Takayoshi Hisada,Akira Honda,Yasushi Matsuzaki,Toshikazu Yoshikawa +13 more
TL;DR: Oral intake of AGO prevents HFD-induced gut dysbiosis, thereby inhibiting colon carcinogenesis, and results show that AGO supplementation suppressed the azoxymethane-induced generation of aberrant crypt foci in the colon derived from H FD-treated mice.