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Yasuo Shimizu
Researcher at Dokkyo Medical University
Publications - 90
Citations - 1913
Yasuo Shimizu is an academic researcher from Dokkyo Medical University. The author has contributed to research in topics: Asthma & Immunoglobulin E. The author has an hindex of 23, co-authored 85 publications receiving 1793 citations. Previous affiliations of Yasuo Shimizu include Gunma University & Dokkyo University.
Papers
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Journal ArticleDOI
Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma.
Haruka Aoki,Takeshi Hisada,Tamotsu Ishizuka,Mitsuyoshi Utsugi,Tadayoshi Kawata,Yasuo Shimizu,Fumikazu Okajima,Kunio Dobashi,Masatomo Mori +8 more
TL;DR: Findings provide evidence that RvE1 is a pivotal counterregulatory signal in allergic inflammation and offer novel multi-pronged therapeutic approaches for human asthma.
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Regulation of LPS induced IL‐12 production by IFN‐γ and IL‐4 through intracellular glutathione status in human alveolar macrophages
Kunio Dobashi,Masayuki Aihara,T. Araki,Yasuo Shimizu,Mitsuyoshi Utsugi,Kunihiko Iizuka,Yukie Murata,Junji Hamuro,Tsugio Nakazawa,Masatomo Mori +9 more
TL;DR: It is suggested that IFN‐γ and IL‐4 oppositely affect the GSH/GSSG balance, which may regulate IL‐12 secretion from AM in response to LPS.
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C-Jun-NH2-Terminal Kinase Mediates Expression of Connective Tissue Growth Factor Induced by Transforming Growth Factor-β1 in Human Lung Fibroblasts
Mitsuyoshi Utsugi,Kunio Dobashi,Tamotsu Ishizuka,Ken Masubuchi,Yasuo Shimizu,Tsugio Nakazawa,Masatomo Mori +6 more
TL;DR: The results suggest that TGF-beta1-induced CTGF mRNA expression is mediated through the JNK-dependent pathway, whereas p38 MAP kinase and ERK pathways minimally contribute.
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Evaluation of Y-27632, a rho-kinase inhibitor, as a bronchodilator in guinea pigs
Kunihiko Iizuka,Yasuo Shimizu,Hideo Tsukagoshi,Akihiro Yoshii,Takashi Harada,Kunio Dobashi,Takahiro Murozono,Tsugio Nakazawa,Masatomo Mori +8 more
TL;DR: Although Y-27632 is not as potent as a beta-adrenoceptor agonist, it is concluded that it may become an alternative inhaled bronchodilator, because Y- 27632 is more potent than theophylline, and the relaxant effect is independent of beta- adrenoceptors.
Journal ArticleDOI
Glutathione redox regulates airway hyperresponsiveness and airway inflammation in mice.
Yoko Koike,Takeshi Hisada,Mitsuyoshi Utsugi,Tamotsu Ishizuka,Yasuo Shimizu,Akihiro Ono,Yukie Murata,Junji Hamuro,Masatomo Mori,Kunio Dobashi +9 more
TL;DR: Changing glutathione redox balance, increase in GSH level, and the GSH/GSSG ratio by gamma-GCE, is suggested to ameliorate bronchial asthma by altering the Th1/Th2 imbalance through IL-12 production from APC and suppressing chemokine production and eosinophil migration itself.