Y
Yi Ban
Researcher at University of Medicine and Dentistry of New Jersey
Publications - 8
Citations - 677
Yi Ban is an academic researcher from University of Medicine and Dentistry of New Jersey. The author has contributed to research in topics: Cancer research & Biology. The author has an hindex of 3, co-authored 3 publications receiving 589 citations. Previous affiliations of Yi Ban include Rutgers University.
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Journal ArticleDOI
Topoisomerase IIβ–Mediated DNA Double-Strand Breaks: Implications in Doxorubicin Cardiotoxicity and Prevention by Dexrazoxane
TL;DR: It is shown that dexrazoxane specifically abolished the DNA damage signal gamma-H2AX induced by doxorubicin, but not camptothecin or hydrogen peroxide, in H9C2 cardiomyocytes, and this results suggest that dex Razoxane antagonizesDoxorubsicin-induced DNA damage through its interference with Top2beta, which could implicate Top2 beta indoxorUBicin cardiotoxicity.
Journal ArticleDOI
A Ubiquitin-Proteasome Pathway for the Repair of Topoisomerase I-DNA Covalent Complexes
TL;DR: Results support a model in which Top1 cleavage complexes arrest transcription and activate a ubiquitin-proteasome pathway leading to the degradation of Top1 Cleavage complexes.
Journal ArticleDOI
Proteasome-dependent Processing of Topoisomerase I-DNA Adducts into DNA Double Strand Breaks at Arrested Replication Forks
TL;DR: It is shown that the formation of replication-dependent DSBs requires the ubiquitin-proteasome pathway in CPT-treated cells, and results support a replication fork collision model in which Top1 cleavage complexes at the arrested replication forks are degraded by proteasome prior to replication fork runoff on the leading strand to generate D SBs.
Journal ArticleDOI
Abstract 603: Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway to generate TCF1+ progenitor CD8+ T cells to improve checkpoint blockade
Geoffrey J. Markowitz,Yi Ban,Diamile Tavarez,Michael J. Crowley,Liron Yoffe,Mitchell Martin,Tito A. Sandoval,Ding Cheng Gao,Juan R. Cubillos-Ruiz,Timothy E. McGraw,Nasser K. Altorki,Vivek Mittal +11 more
TL;DR: Markowitz et al. as mentioned in this paper showed that deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathway activity, leading to generation of an altered differentiation state responsive to PD-1 blockade.
Proceedings ArticleDOI
965 Deficiency of metabolic regulator PKM2 activates the pentose phosphate pathway to generate TCF1+ progenitor CD8 T cells to improve efficacy of PD-1 checkpoint blockade
Geoffrey J. Markowitz,Yi Ban,Diamile Tavarez,Michael Crowley,Liron Yoffe,Mitchell Martin,Tito A. Sandoval,Ding Cheng Gao,Juan R. Cubillos-Ruiz,Timothy E. McGraw,Nasser K. Altorki,Vivek Mittal +11 more
TL;DR: Siddiqui et al. as discussed by the authors showed that deletion of pyruvate kinase muscle 2 (PKM2) results in elevated pentose phosphate pathway activity, leading to generation of an altered differentiation state responsive to checkpoint blockade.