Yi Chen

TL;DR: Overall, this study uncovered a positive feedback loop in the metabolism of CXCL14-positive CAFs and ovarian cancer cells that is critical for metastatic progression.

TL;DR: The intricate mechanisms of Sirtuin 3 in human diseases, and recent notable advances in the field of small-molecule activators or inhibitors targeting SIRT3 as well as their potential therapeutic applications for future drug discovery are summarized.

TL;DR: It is shown that itraconazole inhibits the proliferation of glioblastoma cells both in vitro and in vivo, suggesting an antitumor effect of autophagy in response to itrconazole treatment.

TL;DR: Understanding the complex role of ROS/RNS‐induced redox signaling in inflammation will assist in the design of relevant therapeutic intervention strategies for inflammation‐associated diseases, with a focus on redox modifications of inflammation‐related proteins.

TL;DR: Proteomic analyses reveal that coculture with tumor-associated fibroblasts (TAF) induces significant overexpression of FGFR4, but not other FGFRs, in colorectal cancer cell lines, and suggests novel therapeutic opportunities for the treatment of coloreCTal cancer.