Yi Kai Ng

TL;DR: An LC-MS-based metabolomics approach was used to characterise the variation in secondary metabolite production due to changes in the salt content of the growth media as well as across different growth periods (incubation times), and indicated that a 14 day incubation period is optimal for the maximum production of rifamycin B.

TL;DR: In this paper, the authors investigated the species-level chemical diversity of the two marine actinobacterial species Salinispora arenicola and S. pacifica, isolated from sponges distributed across the Great Barrier Reef (GBR) using LC-MS-based metabolomics.

TL;DR: Evidence for antagonism of sponge-derived Salinispora against sponge- derived Mycobacterium strains from the same sponge specimen and the production of antimycobacterial antibiotics by this Salinipora strain suggest that the synthesis of such antibiotics may have functions in competition between sponge microbial community members.

TL;DR: To investigate the effects of growth conditions related to marine habitat on antibiotic production in sponge‐derived Salinispora actinobacteria, a phytochemical process called ‘spatially aggregating’ is studied.

TL;DR: The developmental cycle of the obligate marine antibiotic producer actinobacterium Salinispora arenicola isolated from a Great Barrier Reef marine sponge was investigated in relation to mycelium and spore ultrastructure, synthesis of rifamycin antibiotic compounds, and expression of genes correlated with spore formation and with r ifamycin precursor synthesis.