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Yi Li Min
Researcher at University of Texas Southwestern Medical Center
Publications - 16
Citations - 1134
Yi Li Min is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin. The author has an hindex of 10, co-authored 15 publications receiving 657 citations. Previous affiliations of Yi Li Min include Tzu Chi University & University of Texas System.
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Journal ArticleDOI
Systemic nanoparticle delivery of CRISPR-Cas9 ribonucleoproteins for effective tissue specific genome editing.
TL;DR: A generalizable methodology is reported that allows engineering of modified lipid nanoparticles to efficiently deliver RNPs into cells and edit tissues including muscle, brain, liver, and lungs to facilitate broad nanoparticle development for a variety of disease targets amenable to protein delivery and precise gene correction approaches.
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Correction of diverse muscular dystrophy mutations in human engineered heart muscle by single-site genome editing
Chengzu Long,Hui Li,Malte Tiburcy,Cristina Rodriguez-Caycedo,Viktoriia Kyrychenko,Huanyu Zhou,Yu Zhang,Yi Li Min,John M. Shelton,Pradeep P.A. Mammen,Norman Y. Liaw,Wolfram-Hubertus Zimmermann,Rhonda Bassel-Duby,Jay W. Schneider,Eric N. Olson +14 more
TL;DR: It is concluded that abolishing conserved RNA splicing acceptor/donor sites and directing the splicing machinery to skip mutant or out-of-frame exons through myoediting allow correction of the cardiac abnormalities associated with DMD by eliminating the underlying genetic basis of the disease.
Journal ArticleDOI
CRISPR-Cas9 corrects Duchenne muscular dystrophy exon 44 deletion mutations in mice and human cells
Yi Li Min,Hui Li,Cristina Rodriguez-Caycedo,Alex A. Mireault,Jian Huang,John M. Shelton,John R. McAnally,Leonela Amoasii,Pradeep P.A. Mammen,Rhonda Bassel-Duby,Eric N. Olson +10 more
TL;DR: This work presents a simple and efficient strategy for correction of exon 44 deletion mutations by CRISPR-Cas9 gene editing in cardiomyocytes obtained from patient-derived induced pluripotent stem cells and in a new mouse model harboring the same deletion mutation.
Journal ArticleDOI
CRISPR Correction of Duchenne Muscular Dystrophy
TL;DR: Using CRISPR to bypass DMD mutations, dystrophin expression has been efficiently restored in human cells and mouse models of DMD.
Journal ArticleDOI
Enhanced CRISPR-Cas9 correction of Duchenne muscular dystrophy in mice by a self-complementary AAV delivery system
Yu Zhang,Hui Li,Yi Li Min,Efrain Sanchez-Ortiz,Jian Huang,Alex A. Mireault,John M. Shelton,Jiwoong Kim,Pradeep P.A. Mammen,Rhonda Bassel-Duby,Eric N. Olson +10 more
TL;DR: Findings show that the efficiency of CRISPR-Cas9–mediated genome editing can be substantially improved by using the scAAV system, and represents an important advancement toward therapeutic translation of genome editing for DMD.