Malte Tiburcy

TL;DR: A proof-of-concept for a universally applicable technology for the engineering of macroscale human myocardium for disease modeling and heart repair from embryonic and induced pluripotent stem cell–derived cardiomyocytes under defined, serum-free conditions is provided.

TL;DR: It is demonstrated that the ERK1/2 signaling pathway uniquely regulates the balance between eccentric and concentric growth of the heart.

TL;DR: It is concluded that abolishing conserved RNA splicing acceptor/donor sites and directing the splicing machinery to skip mutant or out-of-frame exons through myoediting allow correction of the cardiac abnormalities associated with DMD by eliminating the underlying genetic basis of the disease.

TL;DR: EHM transplantation led to high engraftment rates, long-term survival, and progressive maturation of human cardiomyocytes, and the safety of this approach was demonstrated by the lack of tumor or teratoma formation.

TL;DR: An update on the state of cardiac muscle engineering and its utilization in cardiac regeneration is provided and the application of stem cells including the allocation of autologous cell material, transgenic technologies that may improve tissue structure as well as in vivo engraftment, and vascularization concepts are discussed.