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Yi-Ming Chiang
Researcher at University of Southern California
Publications - 88
Citations - 5438
Yi-Ming Chiang is an academic researcher from University of Southern California. The author has contributed to research in topics: Aspergillus nidulans & Gene. The author has an hindex of 39, co-authored 83 publications receiving 4719 citations. Previous affiliations of Yi-Ming Chiang include Academia Sinica & Pacific Northwest National Laboratory.
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Journal ArticleDOI
Chromatin-level regulation of biosynthetic gene clusters
Jin Woo Bok,Yi-Ming Chiang,Yi-Ming Chiang,Edyta Szewczyk,Edyta Szewczyk,Yazmid Reyes-Dominguez,Ashley D. Davidson,James F. Sanchez,Hsien-Chun Lo,Kenji Watanabe,Joseph Strauss,Berl R. Oakley,Berl R. Oakley,Clay C. C. Wang,Nancy P. Keller +14 more
TL;DR: Loss-of-function Aspergillus nidulans CclA, a Bre2 ortholog involved in histone H3 lysine 4 methylation, activated the expression of cryptic secondary metabolite clusters in A. niduans, which generated monodictyphenone, emodin and emod in derivatives and encoded two anti-osteoporosis polyketides.
Journal ArticleDOI
A Gene Cluster Containing Two Fungal Polyketide Synthases Encodes the Biosynthetic Pathway for a Polyketide, Asperfuranone, in Aspergillus nidulans
Yi-Ming Chiang,Edyta Szewczyk,Ashley D. Davidson,Nancy Keller,Berl R. Oakley,Clay C. C. Wang +5 more
TL;DR: The genome sequencing of Aspergillus species including A. nidulans reveals that the products of many of the secondary metabolism pathways in these fungi have not been elucidated, and a series of gene deletions has allowed it to be confirmed that the two PKSs together with five additional genes comprise the asperfuranone biosynthetic pathway.
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Two separate gene clusters encode the biosynthetic pathway for the meroterpenoids, austinol and dehydroaustinol in Aspergillus nidulans
Hsien-Chun Lo,Ruth Entwistle,Chun-Jun Guo,Manmeet Ahuja,Edyta Szewczyk,Jui-Hsiang Hung,Yi-Ming Chiang,Berl R. Oakley,Clay C. C. Wang +8 more
TL;DR: Chemical analysis of mutant extracts enabled us to isolate 3,5-dimethylorsellinic acid and 10 additional meroterpenoids that are either intermediates or shunt products from the biosynthetic pathway, and allow us to propose a complete biosynthesis pathway for the A. nidulans meroter penoids.
Journal ArticleDOI
Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells
Clay C. C. Wang,Yi-Ming Chiang,Yi-Ming Chiang,Shu-Chiao Sung,Ya-Ling Hsu,Jiunn-Kae Chang,Po-Lin Kuo +6 more
TL;DR: A critical role for ROS and JNK in the plumbagin's anticancer activity is found, and it is found the generation of ROS is a critical mediator in plumberagin-induced cell growth inhibition.
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Molecular Genetic Mining of the Aspergillus Secondary Metabolome: Discovery of the Emericellamide Biosynthetic Pathway
Yi-Ming Chiang,Edyta Szewczyk,Tania Nayak,Ashley D. Davidson,James F. Sanchez,Hsien-Chun Lo,Wen-Yueh Ho,Hagop Simityan,Eric J. Kuo,Alex P. Praseuth,Kenji Watanabe,Berl R. Oakley,Clay C. C. Wang +12 more
TL;DR: The recently sequenced genomes of several Aspergillus species are found to produce emericellamide A, an antibiotic compound of mixed origins with polyketide and amino acid building blocks, and four previously unidentified, related compounds that are described.