Y
Yi Xie
Researcher at University of Maryland, Baltimore
Publications - 8
Citations - 466
Yi Xie is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Promoter & Response element. The author has an hindex of 5, co-authored 8 publications receiving 405 citations. Previous affiliations of Yi Xie include University of Maryland Marlene and Stewart Greenebaum Cancer Center.
Papers
More filters
Journal ArticleDOI
Role of breast cancer resistance protein (BCRP/ABCG2) in cancer drug resistance.
TL;DR: Evidence is mounting that many cancers display subpopulations of stem cells that are responsible for tumor self-renewal, and stem cells frequently manifest the "side population" phenotype characterized by expression of BCRP and other ABC transporters, which may contribute to the inherent resistance of these neoplasms and their failure to be cured.
Journal ArticleDOI
A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.
Leslie M. Tompkins,Haishan Li,Linhao Li,Caitlin Lynch,Yi Xie,Takeo Nakanishi,Douglas D. Ross,Douglas D. Ross,Hongbing Wang +8 more
TL;DR: Data show that the novel distal AhRE5 is critical for AhR-mediated transcriptional activation of ABCG2 gene expression in LS174T cells, and it may offer new strategies for early identification ofABCG2 inducers, which would be of benefit for preventing transporter-associated drug-drug interactions.
Journal ArticleDOI
Identification and characterization of the major alternative promoter regulating Bcrp1/Abcg2 expression in the mouse intestine
TL;DR: Mouse intestinal Bcrp1 expression is regulated by a single alternative promoter upstream of E1b, the predominant BCrp1 mRNA isoform expressed in the mouse intestine, and p-CREB to its cis site on the mouse E1B promoter region is regulated.
Journal ArticleDOI
Functional cyclic AMP response element in the breast cancer resistance protein (BCRP/ABCG2) promoter modulates epidermal growth factor receptor pathway- or androgen withdrawal-mediated BCRP/ABCG2 transcription in human cancer cells.
Yi Xie,Takeo Nakanishi,Karthika Natarajan,Lowell Safren,Anne W. Hamburger,Arif Hussain,Douglas D. Ross +6 more
TL;DR: Ch Chromatin immunoprecipitation assays confirmed that a putative CRE site on the BCRP promoter bound p-CREB by a point mutation of the CRE site abolished EGF-induced stimulation of B CRP promoter reporter activity, which plays a central role in mediating BCRp gene expression in several human cancer cell lines following activation of multiple cancer-relevant signaling pathways.
Journal ArticleDOI
Metformin and Androgen Receptor-Axis-Targeted (ARAT) Agents Induce Two PARP-1-Dependent Cell Death Pathways in Androgen-Sensitive Human Prostate Cancer Cells.
Yi Xie,Linbo Wang,Mohammad Afnan Khan,Anne W. Hamburger,Wei Guang,Antonino Passaniti,Antonino Passaniti,Kashif M. Munir,Douglas D. Ross,Michael Dean,Arif Hussain +10 more
TL;DR: In this paper, the anti-prostate cancer (PC) activity of the androgen receptor-axis-targeted agents (ARATs) abiraterone and enzalutamide is enhanced by metformin using complementary biological and molecular approaches.