Y
Ying Yang
Researcher at Sichuan University
Publications - 16
Citations - 147
Ying Yang is an academic researcher from Sichuan University. The author has contributed to research in topics: Medicine & Lung cancer. The author has an hindex of 3, co-authored 5 publications receiving 19 citations.
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Deciphering cell lineage specification of human lung adenocarcinoma with single-cell RNA sequencing.
Zhoufeng Wang,Zhoufeng Wang,Zhe Li,Kun Zhou,Kun Zhou,Chengdi Wang,Lili Jiang,Li Zhang,Ying Yang,Wenxin Luo,Wenliang Qiao,Gang Wang,Yinyun Ni,Shuiping Dai,Tingting Guo,Guiyi Ji,Minjie Xu,Yiying Liu,Zhixi Su,Guowei Che,Li Weimin,Li Weimin +21 more
TL;DR: The data identified a new mechanism in LUAD evolution, provided a robust basis for diagnosis and treatment of LUAD, and identified new markers including miRNA10 and β-hydroxybutyric acid to diagnose early-stage LUAD noninvasively in the blood.
Journal ArticleDOI
miR-15a-5p inhibits metastasis and lipid metabolism by suppressing histone acetylation in lung cancer.
TL;DR: A novel mechanism of miR-15a-5p is unveiled in inhibiting metastasis of lung cancer cells by suppressing lipid metabolism via suppression of ACSS2 mediated acetyl-CoA activity and histone acetylation.
Journal ArticleDOI
FRK plays an oncogenic role in non-small cell lung cancer by enhancing the stemness phenotype via induction of metabolic reprogramming.
Li Zhang,Yongfeng Yang,Li Chai,Hong Bu,Ying Yang,Hong Huang,Jingjing Ran,Yihan Zhu,Li Li,Fei Chen,Weimin Li +10 more
TL;DR: FRK plays an oncogenic role in lung cancer cells via a novel regulation mechanism of enhancing the stemness of H1299 cells by inducing metabolism reprogramming, which finally promotes EMT and metastasis and indicates that FRK could be used as a potential therapeutic target for drug development.
Journal ArticleDOI
The heterogeneous immune landscape between lung adenocarcinoma and squamous carcinoma revealed by single-cell RNA sequencing
Chengdi Wang,Qiuxiao Yu,Tingting Song,Zhoufeng Wang,Lujia Song,Ying Yang,Jun Shao,Jingwei Li,Yinyun Ni,Ningning Chao,Li Zhang,Weimin Li +11 more
TL;DR: In this article , the authors performed scRNA-seq on 72,475 immune cells from 40 samples of tumor and matched adjacent normal tissues spanning 19 NSCLC patients, and drew a systematic immune cell transcriptome atlas.
Journal ArticleDOI
Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer
Li Zhang,Yiming Zhang,Chengdi Wang,Ying Yang,Yinyun Ni,Zhoufeng Wang,Tingting Song,Menglin Yao,Zhiqiang Liu,Ningning Chao,Yongfeng Yang,Jun Shao,Zhidan Li,Ran Zhou,Li Chen,Dan Dan Zhang,Yuancun Zhao,Wei Li,Yupeng Li,Ping He,Jing-wen Lin,Yuan Wang,Kang Zhang,Lu Chen,Weimin Li +24 more
TL;DR: In this article , a multi-omics atlas integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing was established, which revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells.