Wayne C. Drevets

TL;DR: Findings implicate interconnected neural circuits in which pathologic patterns of neurotransmission may result in the emotional, motivational, cognitive, and behavioral manifestations of primary and secondary affective disorders.

TL;DR: A neural model of emotion regulation that includes neural systems implicated in different voluntary and automatic emotion regulatory subprocesses is developed and used as a theoretical framework to examine functional neural abnormalities in these neural systems that may predispose to the development of a major psychiatric disorder, bipolar disorder.

TL;DR: The preferential sensitivity of the ventral Striatum to the DA releasing effects of AMPH previously demonstrated in experimental animals extends to humans and the magnitude of ventral striatal DA release correlates positively with the hedonic response to AMPH.

TL;DR: Serotonin-1A receptor BP is abnormally decreased in the depressed phase of familial mood disorders in multiple brain regions and may be associated with histopathological changes involving the raphe, convergence evidence from postmortem studies of mood disorders suggests.

TL;DR: Physiological activity is decreased in dorsal PFC areas implicated in language, selective attention, visuospatial or mnemonic processing, but these abnormalities reverse with symptom remission, and may relate to the subtle cognitive impairments associated with MDE.