Y
Yong Wei
Researcher at National Institutes of Health
Publications - 4
Citations - 1330
Yong Wei is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Neurodegeneration & Nicotinamide adenine dinucleotide. The author has an hindex of 2, co-authored 2 publications receiving 470 citations. Previous affiliations of Yong Wei include Wuhan University.
Papers
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Journal ArticleDOI
Ageing as a risk factor for neurodegenerative disease.
Yujun Hou,Xiuli Dan,Mansi Babbar,Yong Wei,Steen G. Hasselbalch,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +7 more
TL;DR: Hallmarks of ageing — genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, mitochondrial dysfunction, cellular senescence, stem cell exhaustion and altered intercellular communication — correlate with susceptibility to neurodegenerative disease.
Journal ArticleDOI
NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer's disease via cGAS-STING.
Yujun Hou,Yujun Hou,Yong Wei,Yong Wei,Sofie Lautrup,Sofie Lautrup,Beimeng Yang,Yue Wang,Stephanie Cordonnier,Mark P. Mattson,Deborah L. Croteau,Vilhelm A. Bohr,Vilhelm A. Bohr +12 more
TL;DR: In this paper, the effects of nicotinamide riboside (NR) for 5 mo increased brain NAD+ levels, reduced expression of proinflammatory cytokines, and decreased activation of microglia and astrocytes.
Journal ArticleDOI
Autophagy Balances Neuroinflammation in Alzheimer’s Disease
TL;DR: It is believed that understanding the relationship between autophagy and inflammation will provide insightful knowledge for future therapeutic implications in AD and this review provides an overview of updated information on autophagic and inflammation and their potential mediators in AD.
Journal ArticleDOI
Nicotinamide adenine dinucleotide supplementation drives gut microbiota variation in Alzheimer’s mouse model
Xixia Chu,Yujun Hou,Qiong Meng,Deborah L. Croteau,Yong Wei,Supriyo De,Kevin G. Becker,Vilhelm A. Bohr +7 more
TL;DR: The results indicate an interplay between NR and host-microbiota in APP/PS1 mice, suggesting that the effect of NR on gut dysbiosis may be an important component in its therapeutic functions in AD.