S
Sofie Lautrup
Researcher at Akershus University Hospital
Publications - 22
Citations - 2846
Sofie Lautrup is an academic researcher from Akershus University Hospital. The author has contributed to research in topics: Mitophagy & Medicine. The author has an hindex of 11, co-authored 15 publications receiving 1398 citations. Previous affiliations of Sofie Lautrup include Aarhus University & National Institutes of Health.
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Journal ArticleDOI
Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
Evandro Fei Fang,Yujun Hou,Konstantinos Palikaras,Bryan A. Adriaanse,Jesse S. Kerr,Beimeng Yang,Sofie Lautrup,Mahdi Hasan-Olive,Domenica Caponio,Xiuli Dan,P Rocktäschel,Deborah L. Croteau,Mansour Akbari,Nigel H. Greig,Tormod Fladby,Hilde Nilsen,M Z Cader,Mark P. Mattson,Nektarios Tavernarakis,Nektarios Tavernarakis,Vilhelm A. Bohr,Vilhelm A. Bohr +21 more
TL;DR: Evidence that mitophagy is impaired in the hippocampus of AD patients, in induced pluripotent stem cell-derived human AD neurons, and in animal AD models is provided, suggesting that impaired removal of defective mitochondria is a pivotal event in AD pathogenesis and thatMitophagy represents a potential therapeutic intervention.
Journal ArticleDOI
NAD+ in Brain Aging and Neurodegenerative Disorders
TL;DR: In this article, the role of NAD+ and related metabolites in the adaptation of neurons to a wide range of physiological stressors and in counteracting processes in neurodegenerative diseases, such as those occurring in Alzheimer's, Parkinson's, and Huntington diseases, and amyotrophic lateral sclerosis.
Journal ArticleDOI
NAD+ in Aging: Molecular Mechanisms and Translational Implications
Evandro Fei Fang,Evandro Fei Fang,Sofie Lautrup,Sofie Lautrup,Yujun Hou,Tyler G Demarest,Deborah L. Croteau,Mark P. Mattson,Mark P. Mattson,Vilhelm A. Bohr,Vilhelm A. Bohr +10 more
TL;DR: Technological and pharmacological interventions bolstering cellular NAD+ levels might retard aspects of aging and forestall some age-related diseases.
Journal ArticleDOI
NAD + supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency.
Yujun Hou,Sofie Lautrup,Sofie Lautrup,Stephanie Cordonnier,Yue Wang,Deborah L. Croteau,Eduardo Zavala,Yongqing Zhang,Kanako Moritoh,Jennifer F. O’Connell,Beverly A. Baptiste,Tinna Stevnsner,Mark P. Mattson,Mark P. Mattson,Vilhelm A. Bohr +14 more
TL;DR: It is shown that NAD+ levels were decreased in a new AD mouse model with introduced DNA repair deficiency (3xTgAD/Polβ+/−), and NAD+ supplementation with nicotinamide riboside significantly normalized neuroinflammation, synaptic transmission, phosphorylated Tau, and DNA damage as well as improved learning and memory and motor function.
Journal ArticleDOI
Mitophagy in neurodegeneration and aging.
Elayne M. Fivenson,Sofie Lautrup,Nuo Sun,Morten Scheibye-Knudsen,Tinna Stevnsner,Hilde Nilsen,Vilhelm A. Bohr,Vilhelm A. Bohr,Evandro Fei Fang +8 more
TL;DR: An updated mechanistic overview ofMitophagy pathways is provided and potential translational applications of mitophagy‐inducing compounds, such as NAD+ precursors and urolithins are highlighted.